Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 349372..349849 Replicon chromosome
Accession NZ_CP075562
Organism Staphylococcus aureus strain Sta2021010

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KI818_RS01790 Protein ID WP_000052076.1
Coordinates 349372..349560 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KI818_RS01795 Protein ID WP_001059690.1
Coordinates 349589..349849 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI818_RS01760 (345375) 345375..345884 + 510 WP_000824480.1 hypothetical protein -
KI818_RS01765 (346225) 346225..346911 + 687 WP_001641381.1 thermonuclease family protein -
KI818_RS01770 (347268) 347268..347468 + 201 WP_001059082.1 cold-shock protein -
KI818_RS01775 (347963) 347963..348181 - 219 WP_000005889.1 hypothetical protein -
KI818_RS01780 (348243) 348243..348527 - 285 WP_001004395.1 hypothetical protein -
KI818_RS01785 (348615) 348615..349184 - 570 WP_234494771.1 lipoprotein N-acylation protein LnsA -
KI818_RS01790 (349372) 349372..349560 - 189 WP_000052076.1 hypothetical protein Toxin
KI818_RS01795 (349589) 349589..349849 - 261 WP_001059690.1 hypothetical protein Antitoxin
KI818_RS01800 (350189) 350189..350392 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KI818_RS01805 (350389) 350389..350625 - 237 WP_000368687.1 hypothetical protein -
KI818_RS01810 (350850) 350850..351431 + 582 WP_001140690.1 histidine phosphatase family protein -
KI818_RS01815 (351504) 351504..352121 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KI818_RS01820 (352275) 352275..352769 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KI818_RS01825 (353168) 353168..353590 - 423 WP_000974447.1 organic hydroperoxide resistance protein -
KI818_RS01830 (353738) 353738..354454 + 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-58)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T203874 WP_000052076.1 NZ_CP075562:c349560-349372 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T203874 NZ_CP100431:c979525-978758 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCACGATGGGATTGTTGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGTGAAAATCTCTTTGACCAGATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAACTGCTGAAGGTTCCGCAGCAGAAGTGCTACAAGAATGCCTATTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAAGGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT203874 WP_001059690.1 NZ_CP075562:c349849-349589 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT203874 NZ_CP100431:c980001-979525 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References