Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801195..801852 Replicon chromosome
Accession NZ_CP075552
Organism Klebsiella pneumoniae strain RGF99-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KI681_RS03975 Protein ID WP_002916310.1
Coordinates 801442..801852 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KI681_RS03970 Protein ID WP_002916312.1
Coordinates 801195..801461 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI681_RS03945 (KI681_03940) 796351..797784 - 1434 WP_064145187.1 6-phospho-beta-glucosidase -
KI681_RS03950 (KI681_03945) 797903..798631 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KI681_RS03955 (KI681_03950) 798681..798992 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KI681_RS03960 (KI681_03955) 799156..799815 + 660 WP_002916317.1 hemolysin III family protein -
KI681_RS03965 (KI681_03960) 799966..800949 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KI681_RS03970 (KI681_03965) 801195..801461 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KI681_RS03975 (KI681_03970) 801442..801852 + 411 WP_002916310.1 protein YgfX Toxin
KI681_RS03980 (KI681_03975) 801859..802380 - 522 WP_004144730.1 flavodoxin FldB -
KI681_RS03985 (KI681_03980) 802481..803377 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KI681_RS03990 (KI681_03985) 803400..804113 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KI681_RS03995 (KI681_03990) 804119..805852 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T203851 WP_002916310.1 NZ_CP075552:801442-801852 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T203851 NZ_CP100418:565419-565679 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT203851 WP_002916312.1 NZ_CP075552:801195-801461 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203851 NZ_CP100418:565196-565417 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References