Detailed information of TA system TA203842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4919228..4920909
• Replicon: chromosome
• Accession: NZ_CP075548
• Organism: Klebsiella pneumoniae strain RGT40-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: KI675_RS24020
• Protein ID: WP_002885155.1
• Coordinates: 4919228..4920145 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A2L1C4M5
• Locus tag: KI675_RS24025
• Protein ID: WP_004192584.1
• Coordinates: 4920151..4920909 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI675_RS24000 (4914534)	4914534..4916054	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
KI675_RS24005 (4916051)	4916051..4917049	+	999	WP_002885172.1	ribose ABC transporter permease	-
KI675_RS24010 (4917080)	4917080..4918021	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KI675_RS24015 (4918096)	4918096..4919103	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
KI675_RS24020 (4919228)	4919228..4920145	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KI675_RS24025 (4920151)	4920151..4920909	-	759	WP_004192584.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KI675_RS24030 (4920995)	4920995..4921723	-	729	WP_002885152.1	response regulator transcription factor	-
KI675_RS24035 (4921996)	4921996..4924143	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KI675_RS24040 (4924373)	4924373..4925059	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T203842 WP_002885155.1 NZ_CP075548:c4920145-4919228 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T203842 NZ_CP100390:c1350506-1350297 [Alkalimarinus sp. A2M4]
ATACCTGATGTAGTTGAAGTTGGGCACGTGATTAAACTATTACAACTTGGTGAAACTTTGCCAGATAAATATGTTGATCA
TTTGTTGTCGGGTAATTGGCAAGGTTACCGTGATTGTCATGTTAAGCCAGATTTAGTTTTGATATATAAAGTAGATAACA
ACTCTTTAAAACTTGCAAGGATTGGAACTCATAGTGAGCTATTTCGCTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT203842 WP_004192584.1 NZ_CP075548:c4920909-4920151 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT203842 NZ_CP100390:c1350196-1349957 [Alkalimarinus sp. A2M4]
ATGCCAAAAAATACCAGTATGACACTTGGTAAGCACTTTGATGGATTTATTGCCAACCAAATTAATGAAGGTCGCTTTGC
CTCAGCAAGTGAAGTTGTTCGAGCTGCGCTTAGAATGTTTGAAGATAACGAAAGAAAGATAGCCGTTCTTAGGCAATTGC
TCGACGAAGGTGAAAAAAGTGGTACGGCAGAGTACAGCTATGAAAGCCTGATGAATGAACTTGATGATGAACTTGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A2L1C4M5