Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4756072..4756588 Replicon chromosome
Accession NZ_CP075548
Organism Klebsiella pneumoniae strain RGT40-1

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag KI675_RS23205 Protein ID WP_004192395.1
Coordinates 4756072..4756356 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag KI675_RS23210 Protein ID WP_004192397.1
Coordinates 4756346..4756588 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI675_RS23180 (4751489) 4751489..4751752 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KI675_RS23185 (4751882) 4751882..4752055 + 174 WP_002886906.1 hypothetical protein -
KI675_RS23190 (4752058) 4752058..4752801 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KI675_RS23195 (4753158) 4753158..4755296 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KI675_RS23200 (4755604) 4755604..4756068 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KI675_RS23205 (4756072) 4756072..4756356 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI675_RS23210 (4756346) 4756346..4756588 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KI675_RS23215 (4756666) 4756666..4758576 - 1911 WP_004152270.1 PRD domain-containing protein -
KI675_RS23220 (4758599) 4758599..4759753 - 1155 WP_004178372.1 lactonase family protein -
KI675_RS23225 (4759820) 4759820..4760560 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T203841 WP_004192395.1 NZ_CP075548:c4756356-4756072 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T203841 NZ_CP100390:c1349957-1349655 [Alkalimarinus sp. A2M4]
ATGGGTACATTTACGCTTACTACTAAAGCTAGAGCTGATTTGAAATCGATTGCGATTTATACCCAACGAAAATGGGGAAA
AGAACAACGTAAAATTTATATACGACAATTTGATGATACGTTTCATATGTTGTCAAAAACCCCAAGAGTTGGAACTGAAT
GCGATTATATTAAGACAGGTTACAGAAAATTCCCAGTTACCAGTCACATTGTTTTTTACCGTGGTACGAGCGAGACAAGT
ATTGAAATCGTTCGTATTTTACATAAAAACATGGATGCGAGAGAAAGACTTGTACACCCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT203841 WP_004192397.1 NZ_CP075548:c4756588-4756346 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT203841 NZ_CP100390:c1350196-1349957 [Alkalimarinus sp. A2M4]
ATGCCAAAAAATACCAGTATGACACTTGGTAAGCACTTTGATGGATTTATTGCCAACCAAATTAATGAAGGTCGCTTTGC
CTCAGCAAGTGAAGTTGTTCGAGCTGCGCTTAGAATGTTTGAAGATAACGAAAGAAAGATAGCCGTTCTTAGGCAATTGC
TCGACGAAGGTGAAAAAAGTGGTACGGCAGAGTACAGCTATGAAAGCCTGATGAATGAACTTGATGATGAACTTGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References