Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4675057..4675736 Replicon chromosome
Accession NZ_CP075548
Organism Klebsiella pneumoniae strain RGT40-1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KI675_RS22860 Protein ID WP_065812068.1
Coordinates 4675057..4675377 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KI675_RS22865 Protein ID WP_063444359.1
Coordinates 4675413..4675736 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI675_RS22830 (4670351) 4670351..4670617 + 267 WP_004178415.1 hypothetical protein -
KI675_RS22835 (4670617) 4670617..4671289 + 673 Protein_4491 DUF4400 domain-containing protein -
KI675_RS22840 (4671300) 4671300..4672184 + 885 WP_004192285.1 RES domain-containing protein -
KI675_RS22845 (4672383) 4672383..4672571 - 189 Protein_4493 transposase -
KI675_RS22850 (4672588) 4672588..4673699 - 1112 Protein_4494 IS3 family transposase -
KI675_RS22855 (4674110) 4674110..4674943 - 834 WP_041162402.1 DUF4942 domain-containing protein -
KI675_RS22860 (4675057) 4675057..4675377 - 321 WP_065812068.1 TA system toxin CbtA family protein Toxin
KI675_RS22865 (4675413) 4675413..4675736 - 324 WP_063444359.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KI675_RS22870 (4675749) 4675749..4676219 - 471 WP_063444360.1 DNA repair protein RadC -
KI675_RS22875 (4676290) 4676290..4677111 - 822 WP_045341626.1 DUF932 domain-containing protein -
KI675_RS22880 (4677221) 4677221..4677682 - 462 WP_063444373.1 IrmA family protein -
KI675_RS22885 (4677814) 4677814..4678461 - 648 WP_063444361.1 hypothetical protein -
KI675_RS22890 (4678467) 4678467..4679168 - 702 WP_065812067.1 WYL domain-containing protein -
KI675_RS22895 (4679381) 4679381..4680256 - 876 WP_065812066.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4664462..4699439 34977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12008.68 Da        Isoelectric Point: 6.0604

>T203840 WP_065812068.1 NZ_CP075548:c4675377-4675057 [Klebsiella pneumoniae]
MYISAVPATVPVSSRLSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDAAIKEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T203840 NZ_CP100390:1347653-1347916 [Alkalimarinus sp. A2M4]
ATGAGTAGCAGGTTGCTTAGTTGGACAGATGAAGCGTGGAATGACTATATTTATTGGCAAGGTCAGGATAAAAAGACTTT
AAAACGTATCAATAAATTAATTAGTGACACAATGCGCTCGCCATTTGAGGGTATAGGTAAACCTGAACCTCTTAAAGAAA
ATTTGTCAGGTTTCTGGTCTCGTAGAATAGATGATACAAATAGGTTAGTGTATGTAGTCAATGACAAAGCATTGACCATA
ATTTCGTGCAGGTATCATTATTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12082.77 Da        Isoelectric Point: 6.6314

>AT203840 WP_063444359.1 NZ_CP075548:c4675736-4675413 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFSPIHLQKLDQAFPLFIEQLENMLRVGELNPHQQYHVT
IQLASLTCIADTRGSCGYVYISIYPTQ

Download         Length: 324 bp

>AT203840 NZ_CP100390:1347406-1347660 [Alkalimarinus sp. A2M4]
ATGAGAGTTGTATCTTTTACTGAAGCAAGAAATGGATTAAAAGCTGTTTTAGATTCTGTCGTTAACGATGCAGATACCAC
CGTTATAACGCGCAGAGACTCAGAGGACGCTGTGGTAATGTCTTTAGATTACTACAATAGTTTAATGGAGACTGTTCATT
TGTTAAGGTCTCCTGCAAATGCCGAGCATCTAAGTAAATCTATAGCGCAATACAAAAGTGGCCAAACAACTCAAAGAGAA
ATAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References