Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2618763..2620351 Replicon chromosome
Accession NZ_CP075548
Organism Klebsiella pneumoniae strain RGT40-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag KI675_RS12845 Protein ID WP_004190166.1
Coordinates 2618763..2620085 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KI675_RS12850 Protein ID WP_002904790.1
Coordinates 2620085..2620351 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI675_RS12830 (2613819) 2613819..2616320 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
KI675_RS12835 (2616308) 2616308..2617312 + 1005 WP_004190163.1 fimbrial protein -
KI675_RS12840 (2617454) 2617454..2618746 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KI675_RS12845 (2618763) 2618763..2620085 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
KI675_RS12850 (2620085) 2620085..2620351 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KI675_RS12855 (2620616) 2620616..2620942 - 327 WP_004143476.1 hydroxyisourate hydrolase -
KI675_RS12860 (2620939) 2620939..2621439 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KI675_RS12865 (2621417) 2621417..2622796 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
KI675_RS12870 (2623142) 2623142..2624296 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
KI675_RS12875 (2624277) 2624277..2625200 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T203836 WP_004190166.1 NZ_CP075548:c2620085-2618763 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T203836 NZ_CP100390:1212461-1212724 [Alkalimarinus sp. A2M4]
ATGAGTAGTAGGCTACTTTGTTGGACTGATGAAGCTTGGAATGATTACGTTTACTGGCAAGGTCAGGACAAAAAGACATT
AAAGCGTATAAACAAATTAATCAGTGACACTAAGCGTTCACCATTTGAGGGTATTGGTAAGCCTGAACCTCTTAAAGAAA
ATTTGTCAGGTTTCTGGTCACGCCGAATTGATGACTCCAATCGTTTAGTTTATGCCGTTGATGATAAAACGCTAACCATA
ATATCGTGCAGGTATCATTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT203836 WP_002904790.1 NZ_CP075548:c2620351-2620085 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT203836 NZ_CP100390:1212214-1212468 [Alkalimarinus sp. A2M4]
ATGAGAGTTGTATCTTTTACTGAAGCAAGAAATGGATTAAAAGCTGTTTTAGACTCTGTCGTTAATGATGCAGACACCAC
TGTTATAACGCGTCGAGATTCAGAAGATGCGGTAGTGATGTCATTAGATTATTACAATAGTTTGATGGAAACAGTTCATT
TATTAAAGTCTCCTGCAAATGCAGAACATTTAAACAAATCAATAGCTCAATATAAAAGTGGTAAAACTACGCAAAGAGAT
ATAGTCGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References