Detailed information of TA system TA203820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4276585..4277510
• Replicon: chromosome
• Accession: NZ_CP075487
• Organism: Escherichia coli strain NT1F34

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IGI26_RS21100
• Protein ID: WP_014640052.1
• Coordinates: 4276585..4276971 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: IGI26_RS21105
• Protein ID: WP_024174200.1
• Coordinates: 4277001..4277510 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGI26_RS21065 (4272131)	4272131..4272331	-	201	WP_000649477.1	YdaS family helix-turn-helix protein	-
IGI26_RS21070 (4272422)	4272422..4273096	+	675	WP_000859461.1	LexA family transcriptional regulator	-
IGI26_RS21075 (4273783)	4273783..4274145	+	363	WP_000135680.1	protein YfdP	-
IGI26_RS21080 (4274211)	4274211..4275035	+	825	WP_000081311.1	DUF2303 family protein	-
IGI26_RS21085 (4275224)	4275224..4276006	+	783	WP_032158411.1	hypothetical protein	-
IGI26_RS21090 (4276043)	4276043..4276324	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
IGI26_RS21095 (4276372)	4276372..4276545	-	174	WP_000390072.1	hypothetical protein	-
IGI26_RS21100 (4276585)	4276585..4276971	-	387	WP_014640052.1	hypothetical protein	Toxin
IGI26_RS21105 (4277001)	4277001..4277510	-	510	WP_024174200.1	Panacea domain-containing protein	Antitoxin
IGI26_RS21110 (4277827)	4277827..4277931	-	105	Protein_4029	tRNA-dihydrouridine synthase	-
IGI26_RS21115 (4278057)	4278057..4279025	-	969	WP_000654812.1	IS5-like element IS903B family transposase	-
IGI26_RS21120 (4279360)	4279360..4280100	-	741	WP_001485178.1	DUF2713 family protein	-
IGI26_RS23770 (4280091)	4280091..4280375	-	285	WP_077492761.1	hypothetical protein	-
IGI26_RS21125 (4280694)	4280694..4281209	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
IGI26_RS21130 (4281251)	4281251..4281460	-	210	WP_001030593.1	CsbD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espX4 / espX4	4251472..4293913	42441
	-	flank	IS/Tn	-	-	4278057..4278980	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T203820 WP_014640052.1 NZ_CP075487:c4276971-4276585 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T203820 NZ_CP100351:3516989-3517267 [Desulfomicrobium sp. ZS1]
TTGAGTCTGACTAAAGTTCGCTGGGCCCGAAATGCCATCAAAGATTTGGAAAGGATTCGGATCTTCCTGGAAGAAACAGC
AGATTCGGAAGTGATGCTTTTCGAGGCTCAAAGAATTTGGGAAAGTTGTCAGCGGTTGAGACAATTTCCGGAAAGCGGAC
GACCAGGCCGGATAGCATTCACCCGCGAGGTTGTTGTTTCACCGTATGTGATTCCGTATCGTGTCAAAAAAAGCGTCGTT
GAAATACTGAATATTTTCCACTCTGCTCAGAAGCGTTAG

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19559.39 Da
• Isoelectric Point: 5.3338

>AT203820 WP_024174200.1 NZ_CP075487:c4277510-4277001 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT203820 NZ_CP100351:3516757-3517002 [Desulfomicrobium sp. ZS1]
ATGAGCACAGTCACCGCTCGCTTGTCAGAGGAAACAGCTCTTAAACTGAGCCAGTTAGCCCAAACAACAAACCGAAGTAA
ATCCTTCATTGTGGCCCAGGCATTGGAACATTTTCTTGATGAACAGGCTTGGCAAGTCGCACAGATTCAAGAAAGCCTTG
CCCAGGCCGATGAGGGAAAGTTTGCTTCCTCCATCGAGGTCCAAGAGGCATTCGGTAAATGGGGGTTGACCGTTGAGTCT
GACTAA