Detailed information of TA system TA020382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1607343..1607955
• Replicon: chromosome
• Accession: NC_002737
• Organism: Streptococcus pyogenes M1 GAS

Toxin (Protein)

• Gene name: parE
• Uniprot ID: J7M9F1
• Locus tag: SPY_RS08030
• Protein ID: WP_010922665.1
• Coordinates: 1607620..1607955 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: SPY_RS08025
• Protein ID: WP_002988079.1
• Coordinates: 1607343..1607630 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPY_RS08000	1602526..1603509	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
SPY_RS08005	1603513..1604442	-	930	WP_010922663.1	tagatose-6-phosphate kinase	-
SPY_RS08010	1604490..1605005	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
SPY_RS08015	1605040..1605468	-	429	WP_010922664.1	galactose-6-phosphate isomerase subunit LacA	-
SPY_RS08020	1605914..1606687	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
SPY_RS08025	1607343..1607630	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
SPY_RS08030	1607620..1607955	+	336	WP_010922665.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPY_RS09320	1608107..1608577	+	471	Protein_1534	integrase	-
SPY_RS08040	1608623..1609060	+	438	WP_111713473.1	site-specific integrase	-
SPY_RS08045	1609180..1609572	-	393	WP_002982716.1	30S ribosomal protein S9	-
SPY_RS08050	1609593..1610039	-	447	WP_010922666.1	50S ribosomal protein L13	-
SPY_RS08055	1610257..1610463	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SPY_RS08060	1610460..1610966	-	507	WP_002988070.1	hypothetical protein	-
SPY_RS08065	1611102..1611962	-	861	WP_002982687.1	DegV family protein	-
SPY_RS08070	1612059..1612577	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13185.99 Da
• Isoelectric Point: 5.2144

>T20382 WP_010922665.1 NC_002737:1607620-1607955 [Streptococcus pyogenes M1 GAS]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T20382 NC_002737:1607620-1607955 [Streptococcus pyogenes M1 GAS]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT20382 WP_002988079.1 NC_002737:1607343-1607630 [Streptococcus pyogenes M1 GAS]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT20382 NC_002737:1607343-1607630 [Streptococcus pyogenes M1 GAS]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: J7M9F1

Antitoxin

• AlphaFold DB: A0A4U7GX94