Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2932183..2933018 | Replicon | chromosome |
| Accession | NZ_CP075487 | ||
| Organism | Escherichia coli strain NT1F34 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | IGI26_RS14755 | Protein ID | WP_000854821.1 |
| Coordinates | 2932183..2932560 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | IGI26_RS14760 | Protein ID | WP_024257643.1 |
| Coordinates | 2932650..2933018 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IGI26_RS14720 (2927376) | 2927376..2929097 | + | 1722 | WP_004015322.1 | cysteine/glutathione ABC transporter ATP-binding protein/permease CydC | - |
| IGI26_RS14725 (2929139) | 2929139..2929843 | + | 705 | WP_001241678.1 | leucyl/phenylalanyl-tRNA--protein transferase | - |
| IGI26_RS14730 (2930128) | 2930128..2930346 | + | 219 | WP_001040187.1 | translation initiation factor IF-1 | - |
| IGI26_RS14740 (2930837) | 2930837..2931679 | - | 843 | WP_193119649.1 | DUF4942 domain-containing protein | - |
| IGI26_RS14745 (2931764) | 2931764..2931961 | - | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| IGI26_RS14750 (2931989) | 2931989..2932186 | - | 198 | Protein_2777 | DUF5983 family protein | - |
| IGI26_RS14755 (2932183) | 2932183..2932560 | - | 378 | WP_000854821.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| IGI26_RS14760 (2932650) | 2932650..2933018 | - | 369 | WP_024257643.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| IGI26_RS14765 (2933098) | 2933098..2933319 | - | 222 | WP_000692309.1 | DUF987 domain-containing protein | - |
| IGI26_RS14770 (2933388) | 2933388..2933864 | - | 477 | WP_001186747.1 | RadC family protein | - |
| IGI26_RS14775 (2933879) | 2933879..2934364 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| IGI26_RS14780 (2934455) | 2934455..2935273 | - | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | mdf(A) | msbA | 2886858..3029446 | 142588 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T203815 WP_000854821.1 NZ_CP075487:c2932560-2932183 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T203815 NZ_CP100351:c1353485-1352979 [Desulfomicrobium sp. ZS1]
GTGACCGAATCGTTTTCCGCCCCCACGCCCTTGACCGCGTCACATGACGTATCCTCCTTTTCCTGCGCGGAGCCGTCGCT
GGGTGACTGGTTGCGTCATCGGGCAATGAAAAACCAAGGCTCCGGCGCAACCCGCACCTATGTGGTCTGTTTCGGCAACA
CGGTCGTCGGCTACTACTCCTTGGCCGTGGGCAGCATCGAGCACCGCTTTGTGGCAGGCTCCATCAAACGCAACATGCCG
GAACCCATTCCCGTCATGATCCTGGCCCGCCTAGCGGTGGACCGGCGGTATGCGGGGCAGTGCATCGGCACGGGCATGCT
GCGCGACGCCCTGCTGCGGACGCTCCAGGCGGCGGAAATCGCGGGAATTCGCGCCATGCTCGTCCATGCCCTCAGTGAAC
AGGCAGCATCCTTTTATCGGAGGCGGGGATTCACGGCGTCGCCCTTTGATCCGCTCGTACTGTTCCTTGCCCTGGACCAT
GTCGGAATCCGGCTTGCCGGTTCATAA
GTGACCGAATCGTTTTCCGCCCCCACGCCCTTGACCGCGTCACATGACGTATCCTCCTTTTCCTGCGCGGAGCCGTCGCT
GGGTGACTGGTTGCGTCATCGGGCAATGAAAAACCAAGGCTCCGGCGCAACCCGCACCTATGTGGTCTGTTTCGGCAACA
CGGTCGTCGGCTACTACTCCTTGGCCGTGGGCAGCATCGAGCACCGCTTTGTGGCAGGCTCCATCAAACGCAACATGCCG
GAACCCATTCCCGTCATGATCCTGGCCCGCCTAGCGGTGGACCGGCGGTATGCGGGGCAGTGCATCGGCACGGGCATGCT
GCGCGACGCCCTGCTGCGGACGCTCCAGGCGGCGGAAATCGCGGGAATTCGCGCCATGCTCGTCCATGCCCTCAGTGAAC
AGGCAGCATCCTTTTATCGGAGGCGGGGATTCACGGCGTCGCCCTTTGATCCGCTCGTACTGTTCCTTGCCCTGGACCAT
GTCGGAATCCGGCTTGCCGGTTCATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13678.33 Da Isoelectric Point: 6.4768
>AT203815 WP_024257643.1 NZ_CP075487:c2933018-2932650 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGQPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFSGTTHPDDNHDRPWWGQPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT203815 NZ_CP100351:c1353757-1353482 [Desulfomicrobium sp. ZS1]
ATGACCGCCACCGCATCCATCAATCTGCGTATTTCCGACGAGGAAAAGGCCTTGATCGATCAGGCCGCCCAGAGCCTCGG
AAAGAGCCGGACGGCCTTTATTCTCGAAAACACCCTGCGTCTGGCCGAGGAAGTCGTTCTTGACCGCACGCGCTTCACGC
TGGACAGCACGCAGTGGGAACAATTCGGAGCAGCCCTGGACAATCCGCCTTCCGAAGAACAGCTCCAGGGCCTCGCCACC
CTTTTCCAGGCCAAGGCCCCGTGGCAGCAGCAGTGA
ATGACCGCCACCGCATCCATCAATCTGCGTATTTCCGACGAGGAAAAGGCCTTGATCGATCAGGCCGCCCAGAGCCTCGG
AAAGAGCCGGACGGCCTTTATTCTCGAAAACACCCTGCGTCTGGCCGAGGAAGTCGTTCTTGACCGCACGCGCTTCACGC
TGGACAGCACGCAGTGGGAACAATTCGGAGCAGCCCTGGACAATCCGCCTTCCGAAGAACAGCTCCAGGGCCTCGCCACC
CTTTTCCAGGCCAAGGCCCCGTGGCAGCAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|