Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3430829..3431417 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name hicA Uniprot ID Q9A3L9
Locus tag CC_RS16615 Protein ID WP_010921020.1
Coordinates 3430829..3431017 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9A3L8
Locus tag CC_RS16620 Protein ID WP_010921021.1
Coordinates 3431022..3431417 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC_RS16590 (CC_3179) 3426713..3427732 - 1020 WP_024265922.1 amidohydrolase family protein -
CC_RS16595 (CC_3180) 3427908..3428942 + 1035 WP_010921016.1 adenosine deaminase -
CC_RS16600 (CC_3181) 3428953..3429921 + 969 WP_010921017.1 magnesium and cobalt transport protein CorA -
CC_RS16605 (CC_3182) 3429899..3430450 - 552 WP_010921018.1 hypothetical protein -
CC_RS16610 (CC_3183) 3430447..3430752 - 306 WP_010921019.1 PadR family transcriptional regulator -
CC_RS16615 (CC_3184) 3430829..3431017 + 189 WP_010921020.1 type II toxin-antitoxin system HicA family toxin Toxin
CC_RS16620 (CC_3185) 3431022..3431417 + 396 WP_010921021.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CC_RS16625 (CC_3186) 3431426..3431902 - 477 WP_010921022.1 DUF2199 domain-containing protein -
CC_RS16630 (CC_3187) 3431960..3432958 - 999 WP_010921023.1 DegT/DnrJ/EryC1/StrS aminotransferase family protein -
CC_RS16635 (CC_3188) 3433086..3434639 - 1554 WP_010921024.1 acyl--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T20381 WP_010921020.1 NC_002696:3430829-3431017 [Caulobacter vibrioides CB15]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T20381 NC_002696:3430829-3431017 [Caulobacter vibrioides CB15]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT20381 WP_010921021.1 NC_002696:3431022-3431417 [Caulobacter vibrioides CB15]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT20381 NC_002696:3431022-3431417 [Caulobacter vibrioides CB15]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290MM32

Antitoxin

Source ID Structure
AlphaFold DB Q9A3L8

References