20380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 3371212..3371654 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3CB57
Locus tag CC_RS16345 Protein ID WP_012640672.1
Coordinates 3371379..3371654 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID P0CW75
Locus tag CC_RS16340 Protein ID WP_012640671.1
Coordinates 3371212..3371391 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC_RS16325 (CC_3128) 3366270..3368291 - 2022 WP_010920964.1 tetratricopeptide repeat-containing sulfotransferase family protein -
CC_RS16330 (CC_3129) 3368374..3369663 - 1290 WP_010920965.1 FAD-binding oxidoreductase -
CC_RS16335 (CC_3130) 3369739..3371136 - 1398 WP_010920966.1 glutamine synthetase family protein -
CC_RS16340 3371212..3371391 + 180 WP_012640671.1 antitoxin RelB4 Antitoxin
CC_RS16345 (CC_3131) 3371379..3371654 + 276 WP_012640672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CC_RS16350 (CC_3132) 3371657..3373060 - 1404 WP_010920968.1 aspartate aminotransferase family protein -
CC_RS16355 (CC_3133) 3373078..3373827 - 750 WP_012640673.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
CC_RS16360 (CC_3134) 3373832..3374977 - 1146 WP_010920970.1 ABC transporter ATP-binding protein -
CC_RS16365 (CC_3135) 3375123..3375998 - 876 WP_012640674.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10141.74 Da        Isoelectric Point: 11.9574

>T20380 WP_012640672.1 NC_002696:3371379-3371654 [Caulobacter vibrioides CB15]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPI

Download         Length: 276 bp

>T20380 NC_002696:3371379-3371654 [Caulobacter vibrioides CB15]
GTGGCGCAAGTAGTCTGGACCCAACGAGCGATGGCCGATGTTTACGCCATCGTCGGCCATATCTCCGAGCAGTCGCGTCC
TCTCGCGGCCCAGCGCCTGGCCAAGAGGTTGTTCGACACCGGCGCTAGCCTGGCGACCTATCCCGAACGCGGGCGCGTGA
GCACTCAAGGACGGCGTGAGATCGTCGCGATTTCGCCCTACGTTCTGCGCTACCGCATTGTCGGCGACCGTGTCGTCATT
GGCAGCGTACGCCATGGGGCGCGTCGACCTATCTAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6606.17 Da        Isoelectric Point: 3.9689

>AT20380 WP_012640671.1 NC_002696:3371212-3371391 [Caulobacter vibrioides CB15]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK

Download         Length: 180 bp

>AT20380 NC_002696:3371212-3371391 [Caulobacter vibrioides CB15]
ATGGCCGAGCCTGACCCCGACATCTTCGACGAGGACGATGAAGCGATCCTGGCGGCTGACGCCGAGGCTGACGCCGACTT
CGAAGCCGGTAGAACTGTTCCGCACGAGCGTGTGGGCGAGTGGCTCAAGACGTTGGGCACGCCGCACCAGACACCGCCAC
CATATTCGTGGCGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3CB57

Antitoxin

Source ID Structure
AlphaFold DB P0CW75

References