Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3444931..3445549 Replicon chromosome
Accession NZ_CP075484
Organism Escherichia coli strain NT1N25

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IGI28_RS17010 Protein ID WP_001291435.1
Coordinates 3445331..3445549 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IGI28_RS17005 Protein ID WP_000344800.1
Coordinates 3444931..3445305 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGI28_RS16995 (3440020) 3440020..3441213 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IGI28_RS17000 (3441236) 3441236..3444385 + 3150 WP_089674075.1 efflux RND transporter permease AcrB -
IGI28_RS17005 (3444931) 3444931..3445305 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IGI28_RS17010 (3445331) 3445331..3445549 + 219 WP_001291435.1 HHA domain-containing protein Toxin
IGI28_RS17015 (3445721) 3445721..3446272 + 552 WP_000102564.1 maltose O-acetyltransferase -
IGI28_RS17020 (3446388) 3446388..3446858 + 471 WP_000136192.1 YlaC family protein -
IGI28_RS17025 (3447022) 3447022..3448572 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IGI28_RS17030 (3448614) 3448614..3448967 - 354 WP_000878141.1 DUF1428 family protein -
IGI28_RS17040 (3449346) 3449346..3449657 + 312 WP_000409911.1 MGMT family protein -
IGI28_RS17045 (3449688) 3449688..3450260 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T203792 WP_001291435.1 NZ_CP075484:3445331-3445549 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T203792 NZ_CP100334:1652684-1652866 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCTCATGGTTGGACAAAGACCAAAGGCGGTAAGGGGTCACA
CGTTAAACTTGAAAAAGCTGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATATACTGAACGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT203792 WP_000344800.1 NZ_CP075484:3444931-3445305 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT203792 NZ_CP100334:1652905-1653357 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATTCAGACGGAGCTAACGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCACTCCTGCCCCTATTAACACTCTATCTTTAGCAAATAATAACCCTTTC
CGTGATGATGAGGATATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGATGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References