Detailed information of TA system TA020379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2984310..2985973
• Replicon: chromosome
• Accession: NC_002696
• Organism: Caulobacter crescentus CB15

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: Q9A4R0
• Locus tag: CC_RS14460
• Protein ID: WP_010920611.1
• Coordinates: 2984310..2985617 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: CC_RS14465
• Protein ID: WP_010920612.1
• Coordinates: 2985614..2985973 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CC_RS14430 (CC_2764)	2979398..2980768	-	1371	WP_012640579.1	hypothetical protein	-
CC_RS14435 (CC_2765)	2980929..2982326	-	1398	WP_010920606.1	sensor histidine kinase	-
CC_RS14440 (CC_2766)	2982457..2983134	-	678	WP_010920607.1	response regulator transcription factor	-
CC_RS14445 (CC_2767)	2983153..2983470	-	318	WP_010920608.1	PepSY domain-containing protein	-
CC_RS14450 (CC_2768)	2983599..2984108	-	510	WP_010920609.1	hypothetical protein	-
CC_RS14460 (CC_2770)	2984310..2985617	-	1308	WP_010920611.1	type II toxin-antitoxin system HipA family toxin	Toxin
CC_RS14465 (CC_2771)	2985614..2985973	-	360	WP_010920612.1	helix-turn-helix domain-containing protein	Antitoxin
CC_RS14470 (CC_2772)	2986136..2987080	-	945	WP_010920613.1	J domain-containing protein	-
CC_RS14475 (CC_2773)	2987169..2990880	-	3712	Protein_2838	glycoside hydrolase/phage tail family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (170-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 47909.26 Da
• Isoelectric Point: 6.8907

>T20379 WP_010920611.1 NC_002696:c2985617-2984310 [Caulobacter vibrioides CB15]
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR

Nucleotide

• Length: 1308 bp

>T20379 NC_002696:c2985617-2984310 [Caulobacter vibrioides CB15]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13019.91 Da
• Isoelectric Point: 10.1741

>AT20379 WP_010920612.1 NC_002696:c2985973-2985614 [Caulobacter vibrioides CB15]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Nucleotide

• Length: 360 bp

>AT20379 NC_002696:c2985973-2985614 [Caulobacter vibrioides CB15]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA

Structures

Toxin

• AlphaFold DB: Q9A4R0