Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 926053..926707 Replicon chromosome
Accession NZ_CP075484
Organism Escherichia coli strain NT1N25

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag IGI28_RS05015 Protein ID WP_000244772.1
Coordinates 926300..926707 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IGI28_RS05010 Protein ID WP_000354046.1
Coordinates 926053..926319 (+) Length 89 a.a.

Genomic Context

IGI28_RS04985IGI28_RS04995IGI28_RS05000IGI28_RS05010IGI28_RS05015IGI28_RS05025IGI28_RS05030IGI28_RS05035IGI28_RS04990IGI28_RS05005IGI28_RS05020
Location: 921341..922084 (744 bp)
Type: Others
Protein ID: WP_001436959.1
Location: 923619..923930 (312 bp)
Type: Others
Protein ID: WP_001182954.1
Location: 924094..924753 (660 bp)
Type: Others
Protein ID: WP_000250274.1
Location: 926053..926319 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 926300..926707 (408 bp)
Type: Toxin
Protein ID: WP_000244772.1
Location: 927380..928276 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 928301..929011 (711 bp)
Type: Others
Protein ID: WP_000715214.1
Location: 929017..930750 (1734 bp)
Type: Others
Protein ID: WP_000813213.1
Location: 922141..923574 (1434 bp)
Type: Others
Protein ID: WP_001344773.1
Location: 924830..925810 (981 bp)
Type: Others
Protein ID: WP_000886062.1
Location: 926747..927268 (522 bp)
Type: Others
Protein ID: WP_001055874.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IGI28_RS04985 (921341)921341..922084+744WP_001436959.1SDR family oxidoreductase-
IGI28_RS04990 (922141)922141..923574-1434WP_001344773.16-phospho-beta-glucosidase BglA-
IGI28_RS04995 (923619)923619..923930+312WP_001182954.1N(4)-acetylcytidine aminohydrolase-
IGI28_RS05000 (924094)924094..924753+660WP_000250274.1hemolysin III family protein-
IGI28_RS05005 (924830)924830..925810-981WP_000886062.1tRNA-modifying protein YgfZ-
IGI28_RS05010 (926053)926053..926319+267WP_000354046.1FAD assembly factor SdhEAntitoxin
IGI28_RS05015 (926300)926300..926707+408WP_000244772.1protein YgfXToxin
IGI28_RS05020 (926747)926747..927268-522WP_001055874.1flavodoxin FldB-
IGI28_RS05025 (927380)927380..928276+897WP_000806638.1site-specific tyrosine recombinase XerD-
IGI28_RS05030 (928301)928301..929011+711WP_000715214.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
IGI28_RS05035 (929017)929017..930750+1734WP_000813213.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T203777 WP_000244772.1 NZ_CP075484:926300-926707 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T203777 NZ_CP100330:c969884-969618 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT203777 WP_000354046.1 NZ_CP075484:926053-926319 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203777 NZ_CP100330:c970119-969868 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0E0XYB4

Antitoxin

Loading, please wait
Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References