Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 3044569..3045212 | Replicon | chromosome |
Accession | NZ_CP075477 | ||
Organism | Escherichia coli strain NT1W25 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q84A06 |
Locus tag | IGI33_RS14665 | Protein ID | WP_000754566.1 |
Coordinates | 3044569..3044985 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q84A07 |
Locus tag | IGI33_RS14670 | Protein ID | WP_001261276.1 |
Coordinates | 3044982..3045212 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IGI33_RS14635 (3039607) | 3039607..3040338 | + | 732 | WP_001295905.1 | arginine ABC transporter substrate-binding protein ArtJ | - |
IGI33_RS14640 (3040513) | 3040513..3041640 | - | 1128 | WP_001149732.1 | 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC | - |
IGI33_RS14645 (3041681) | 3041681..3042169 | - | 489 | WP_000389260.1 | YbjO family protein | - |
IGI33_RS14650 (3042229) | 3042229..3043074 | - | 846 | WP_001061657.1 | putrescine ABC transporter permease PotI | - |
IGI33_RS14655 (3043071) | 3043071..3043532 | - | 462 | Protein_2871 | ABC transporter permease subunit | - |
IGI33_RS14660 (3043535) | 3043535..3044364 | - | 830 | Protein_2872 | IS3 family transposase | - |
IGI33_RS14665 (3044569) | 3044569..3044985 | - | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
IGI33_RS14670 (3044982) | 3044982..3045212 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
IGI33_RS23510 (3045169) | 3045169..3045423 | + | 255 | Protein_2875 | hypothetical protein | - |
IGI33_RS14675 (3045411) | 3045411..3045902 | - | 492 | Protein_2876 | IS5-like element ISKpn26 family transposase | - |
IGI33_RS14680 (3046205) | 3046205..3047467 | - | 1263 | WP_000608644.1 | IS1380-like element ISEcp1 family transposase | - |
IGI33_RS14685 (3047655) | 3047655..3048149 | - | 495 | Protein_2878 | putrescine ABC transporter permease PotH | - |
IGI33_RS14690 (3048159) | 3048159..3049292 | - | 1134 | WP_000996018.1 | putrescine ABC transporter ATP-binding subunit PotG | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | IScluster/Tn | - | - | 3043502..3047467 | 3965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T203733 WP_000754566.1 NZ_CP075477:c3044985-3044569 [Escherichia coli]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T203733 NZ_CP100305:c2788347-2787958 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT203733 WP_001261276.1 NZ_CP075477:c3045212-3044982 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT203733 NZ_CP100305:c2788611-2788354 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A387K1G3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A387K023 |