Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 268406..269037 Replicon chromosome
Accession NZ_CP075477
Organism Escherichia coli strain NT1W25

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag IGI33_RS01270 Protein ID WP_001259385.1
Coordinates 268406..268681 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag IGI33_RS01275 Protein ID WP_000593554.1
Coordinates 268678..269037 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGI33_RS01255 (263410) 263410..264477 + 1068 WP_000361467.1 HlyD family secretion protein -
IGI33_RS01260 (264474) 264474..267209 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
IGI33_RS01265 (267209) 267209..268333 + 1125 WP_001314210.1 ABC transporter permease -
IGI33_RS01270 (268406) 268406..268681 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
IGI33_RS01275 (268678) 268678..269037 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IGI33_RS01280 (269087) 269087..269947 - 861 WP_001131783.1 class II aldolase -
IGI33_RS01285 (269979) 269979..270248 - 270 WP_000933060.1 HPr family phosphocarrier protein -
IGI33_RS01290 (270238) 270238..271746 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
IGI33_RS01295 (271739) 271739..273097 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
IGI33_RS01300 (273174) 273174..273455 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
IGI33_RS01305 (273452) 273452..273925 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T203715 WP_001259385.1 NZ_CP075477:268406-268681 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T203715 NZ_CP100292:1055841-1056338 [Burkholderia glumae]
ATGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCGGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCAGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT203715 WP_000593554.1 NZ_CP075477:268678-269037 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT203715 NZ_CP100292:1055563-1055844 [Burkholderia glumae]
ATGGCCTCGACCACCCCGCGCGACACCCTGAACTTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTCCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGCCTGGATGCGCCCGCCCAGCCGAACGCGGCACTGCGC
CAGACCATGCAGACGCGCGCGCCCTGGGACCCCGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References