Detailed information of TA system TA203713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4275290..4276215
• Replicon: chromosome
• Accession: NZ_CP075474
• Organism: Escherichia coli strain NT1N28

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IGI29_RS21160
• Protein ID: WP_014640052.1
• Coordinates: 4275290..4275676 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: IGI29_RS21165
• Protein ID: WP_024174200.1
• Coordinates: 4275706..4276215 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGI29_RS21125 (4270836)	4270836..4271036	-	201	WP_000649477.1	YdaS family helix-turn-helix protein	-
IGI29_RS21130 (4271127)	4271127..4271801	+	675	WP_000859461.1	LexA family transcriptional regulator	-
IGI29_RS21135 (4272488)	4272488..4272850	+	363	WP_000135680.1	protein YfdP	-
IGI29_RS21140 (4272916)	4272916..4273740	+	825	WP_000081311.1	DUF2303 family protein	-
IGI29_RS21145 (4273929)	4273929..4274711	+	783	WP_032158411.1	hypothetical protein	-
IGI29_RS21150 (4274748)	4274748..4275029	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
IGI29_RS21155 (4275077)	4275077..4275250	-	174	WP_000390072.1	hypothetical protein	-
IGI29_RS21160 (4275290)	4275290..4275676	-	387	WP_014640052.1	hypothetical protein	Toxin
IGI29_RS21165 (4275706)	4275706..4276215	-	510	WP_024174200.1	Panacea domain-containing protein	Antitoxin
IGI29_RS21170 (4276532)	4276532..4276636	-	105	Protein_4027	tRNA-dihydrouridine synthase	-
IGI29_RS21175 (4276762)	4276762..4277730	-	969	WP_000654812.1	IS5-like element IS903B family transposase	-
IGI29_RS21180 (4278065)	4278065..4278805	-	741	WP_001485178.1	DUF2713 family protein	-
IGI29_RS23825 (4278796)	4278796..4279080	-	285	WP_077492761.1	hypothetical protein	-
IGI29_RS21185 (4279399)	4279399..4279914	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
IGI29_RS21190 (4279956)	4279956..4280165	-	210	WP_001030593.1	CsbD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4259128..4282287	23159
	-	flank	IS/Tn	-	-	4276762..4277685	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T203713 WP_014640052.1 NZ_CP075474:c4275676-4275290 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T203713 NZ_CP100291:2508836-2509018 [Burkholderia glumae]
ATGAACAGCGCGAACCTTATCCGAACCCTGAAAGCCGACGGCTGGTATCTCGTCAACACCGTCGGCTCGCATCACCAGTT
CAAGCATGCGACCAAGCCAGGTAAGGTGACGGTGCCTCACCCGAAGAAAGACCTTCCCCTCGGCACCGTGCGCAGCATCC
TGAAACAAGCCGGTCTGAAATGA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19559.39 Da
• Isoelectric Point: 5.3338

>AT203713 WP_024174200.1 NZ_CP075474:c4276215-4275706 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT203713 NZ_CP100291:2509045-2509440 [Burkholderia glumae]
ATGCTCTATCCGCTCTATGTCCACGTCGGTGACGACAAGCACGCCCACGGTGTCACCTTCCCCGACTTTCCCGGCTGCCA
CGCAGCGGCCGACTCCTGGGACGAGCTGCCTGCAGCCGTGCAGGAGGCCGCGCAGGCTCATTTCGAGGGCGACGACAGCC
CGATTCCCGAGCCTTCCGCGCTCGAAGATTTGACGCGCGATCCGGAATACACCGGCGGCGTCTGGATGATCTTCGATATC
GACCTGTCGAAGATCAACACGAAAGCCGTGCGCTTCAACGTCAGCATGTCCGAGCGGCTGCTCCAGAAGATCGACGCCAA
GGCGCGCGCGCGCAAACTCTCGCGATCGGCCTTCCTTGCGATTGCGGCAGAACACGAAATGGAAGCTGACGCCTAA