Detailed information of TA system TA203683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2298344..2299932
• Replicon: chromosome
• Accession: NZ_CP075472
• Organism: Escherichia coli strain NT1F25

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IGI24_RS11940
• Protein ID: WP_032298984.1
• Coordinates: 2298610..2299932 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IGI24_RS11935
• Protein ID: WP_001301023.1
• Coordinates: 2298344..2298610 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGI24_RS11930 (2293860)	2293860..2298121	+	4262	Protein_2222	ECSE_1600 family autotransporter	-
IGI24_RS11935 (2298344)	2298344..2298610	+	267	WP_001301023.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IGI24_RS11940 (2298610)	2298610..2299932	+	1323	WP_032298984.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
IGI24_RS11945 (2300244)	2300244..2300452	+	209	Protein_2225	AraC family transcriptional regulator	-
IGI24_RS11950 (2300707)	2300707..2301933	+	1227	Protein_2226	fimbria/pilus outer membrane usher protein	-
IGI24_RS11955 (2301947)	2301947..2302312	+	366	Protein_2227	fimbrial protein	-
IGI24_RS11965 (2303083)	2303083..2303253	+	171	Protein_2229	type 1 fimbrial protein	-
IGI24_RS11970 (2303266)	2303266..2303769	+	504	WP_000825452.1	fimbrial protein	-
IGI24_RS11975 (2303828)	2303828..2304742	+	915	WP_000520676.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2293119..2314215	21096

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49305.84 Da
• Isoelectric Point: 8.2482

>T203683 WP_032298984.1 NZ_CP075472:2298610-2299932 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATTKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T203683 NZ_CP100258:c128766-128356 [Burkholderia glumae]
ATGACGCTGTACCTGCTCGACACCAACATCTTGTCCAGCGTGATTCGAGACCCGCGCGGCGCCTGCGCGACCCGGATCGG
ACACACTCAGCCCGAGCAAATTTGCACCTCGATCATCGTCGCGGCGGAACTGCGGTTTGGCGTCTTCAAGCGCGGCTCGC
CGACCCTCGCGCAGCGCGTCGAGCAACTGCTCGCGAGCTTGAGCGTGCTGCCGTTGCAGCCCGATGCTGACCAGTGCTAT
GGCCGGTTGCGGGCCGACCTTGAGAAGCAGGGCCAGTTGATCGGCGCCAACGACATGCTGATCGCCGCGCACGCGCTGGC
GCTCGAGGCCGTCCTGGTGACGGACAACACGGCGGAATTTGCCCGTGTCGCGGGGCTTCCGGTCGAAAACTGGTTGCGGC
CGACGCCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10016.38 Da
• Isoelectric Point: 6.2267

>AT203683 WP_001301023.1 NZ_CP075472:2298344-2298610 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Nucleotide

• Length: 267 bp

>AT203683 NZ_CP100258:c129005-128763 [Burkholderia glumae]
ATGCCCGCACATGACACCCGCCATGCCCGATTGTTTCGCAACGGGCGCAGTCAGGCCGTGCGGATTCCGCGCGAGTTCGA
GCTTTCCGCGTCCGAGGTCACGATCTATCGCGAGGGCGCACGTTTGATCATCGAGCCCGTCCAGGCCGCGCCCTTGCGTG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGACCTTCCCCGACATCGAGAACCTGCCGGCCGAACCGGTCGACATCGAA
TGA