Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2749755..2750475 Replicon chromosome
Accession NC_002695
Organism Escherichia coli O157:H7 str. Sakai

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag ECs_2806 Protein ID NP_310833.1
Coordinates 2750212..2750475 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ECs_2805 Protein ID NP_310832.1
Coordinates 2749755..2750123 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECs_2798 2744988..2746058 + 1071 NP_310825.1 phospholipase -
ECs_2799 2746194..2746877 + 684 NP_310826.1 hypothetical protein -
ECs_2800 2746893..2747303 + 411 NP_310827.1 hypothetical protein -
ECs_2801 2747524..2748345 + 822 NP_310828.1 hypothetical protein -
ECs_2802 2748427..2748906 + 480 NP_310829.1 antirestriction protein -
ECs_2803 2748921..2749397 + 477 NP_310830.1 DNA repair protein -
ECs_2804 2749460..2749681 + 222 NP_310831.1 hypothetical protein -
ECs_2805 2749755..2750123 + 369 NP_310832.1 antitoxin of toxin-antitoxin system Antitoxin
ECs_2806 2750212..2750475 + 264 NP_310833.1 toxin of the YeeV-YeeU toxin-antitoxin system Toxin
ECs_2807 2750582..2750776 + 195 NP_310834.2 hypothetical protein -
ECs_2808 2751217..2751573 + 357 NP_310835.1 hypothetical protein -
ECs_2809 2751674..2752003 - 330 NP_310836.2 hypothetical protein -
ECs_2810 2752175..2753233 - 1059 NP_310837.1 transporter -
ECs_2811 2753432..2753905 - 474 NP_310838.1 DNA gyrase inhibitor -
ECs_2812 2754024..2755190 - 1167 NP_310839.2 D-alanyl-D-alanine carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-73)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9524.96 Da        Isoelectric Point: 4.6251

>T20364 NP_310833.1 NC_002695:2750212-2750475 [Escherichia coli O157:H7 str. Sakai]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVLPTSRDS
APVPALS

Download         Length: 264 bp

>T20364 NC_002695:2750212-2750475 [Escherichia coli O157:H7 str. Sakai]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCTACCGACCAGCCGGGATTCA
GCGCCTGTACCCGCTCTCAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13577.44 Da        Isoelectric Point: 6.3139

>AT20364 NP_310832.1 NC_002695:2749755-2750123 [Escherichia coli O157:H7 str. Sakai]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT20364 NC_002695:2749755-2750123 [Escherichia coli O157:H7 str. Sakai]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References