Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3565236..3566070 Replicon chromosome
Accession NZ_CP075465
Organism Escherichia coli strain NT1N34

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag IGI31_RS17165 Protein ID WP_039025883.1
Coordinates 3565236..3565613 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag IGI31_RS17170 Protein ID WP_039025882.1
Coordinates 3565702..3566070 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGI31_RS17140 (3561207) 3561207..3561359 - 153 WP_000788776.1 hypothetical protein -
IGI31_RS17145 (3562177) 3562177..3563496 + 1320 WP_000144688.1 site-specific integrase -
IGI31_RS17150 (3563589) 3563589..3564437 - 849 WP_039025884.1 DUF4942 domain-containing protein -
IGI31_RS17155 (3564534) 3564534..3564731 - 198 WP_000772024.1 DUF957 domain-containing protein -
IGI31_RS17160 (3564751) 3564751..3565239 - 489 Protein_3376 DUF5983 family protein -
IGI31_RS17165 (3565236) 3565236..3565613 - 378 WP_039025883.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
IGI31_RS17170 (3565702) 3565702..3566070 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IGI31_RS17175 (3566120) 3566120..3566764 - 645 WP_039025881.1 hypothetical protein -
IGI31_RS17180 (3566779) 3566779..3567000 - 222 WP_000692312.1 DUF987 domain-containing protein -
IGI31_RS17185 (3567069) 3567069..3567545 - 477 WP_001186742.1 RadC family protein -
IGI31_RS17190 (3567560) 3567560..3568045 - 486 WP_000214316.1 antirestriction protein -
IGI31_RS17195 (3568136) 3568136..3568954 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T203638 WP_039025883.1 NZ_CP075465:c3565613-3565236 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T203638 NZ_CP100205:c131793-131491 [Burkholderia glumae]
ATGCGGGGTAAGGCGCGGGTGGTGCGGCTGACGCCCTTGGCCGAGGCCGACCTCGAGGACATCTGGGCTTACATCTTCGA
GCAGTGGTCACTCGCGCAGGCCGAGCAATACGTCGGCGAGATCGTCGCTGCCTTCAACCGACTGGCGCGCGGCGAATGGG
TCGGGGCCGTGCGGGGCGAACCTTACCGGCGCTATCTGGTCGGCTTCCATGCGGTGTTTTATCGAGAGACCACCGACGCC
TTGGATGTCGCCTGTGTGCGGCATCAGCGTATGGACGTGGGTTCGCACCTGTCGCAGTATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT203638 WP_039025882.1 NZ_CP075465:c3566070-3565702 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT203638 NZ_CP100205:c132028-131783 [Burkholderia glumae]
ATGCCGCGGAACACATCGATCTCGCTGGGGGATCACCTGACTCAGTTTGTCGACACACAGGTCGCATCCGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGCGCCGGGCTTCGCCTGCTCGAGACGCAGGAAACCGAACTGAAGGCGCTGAAGGAGGCGT
TGCGCGCCAGTGAGGCGTCCGGCGCGCCCGCGGCGTTTGACGGCCAAGCGTTCCTCGACCGCATGCGTGCGAAGCATGCG
GGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References