Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2751130..2751964 | Replicon | chromosome |
| Accession | NZ_CP075465 | ||
| Organism | Escherichia coli strain NT1N34 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | W0S379 |
| Locus tag | IGI31_RS13370 | Protein ID | WP_000854808.1 |
| Coordinates | 2751130..2751507 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | IGI31_RS13375 | Protein ID | WP_214461210.1 |
| Coordinates | 2751596..2751964 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IGI31_RS13330 (2746137) | 2746137..2746628 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| IGI31_RS13335 (2746730) | 2746730..2747284 | - | 555 | WP_001001921.1 | molecular chaperone YcdY | - |
| IGI31_RS13340 (2747308) | 2747308..2748045 | - | 738 | WP_000283667.1 | zinc-binding phosphatase | - |
| IGI31_RS13345 (2748100) | 2748100..2749038 | - | 939 | Protein_2626 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| IGI31_RS13355 (2749509) | 2749509..2750351 | - | 843 | WP_193107732.1 | DUF4942 domain-containing protein | - |
| IGI31_RS13360 (2750436) | 2750436..2750633 | - | 198 | WP_072643848.1 | DUF957 domain-containing protein | - |
| IGI31_RS13365 (2750645) | 2750645..2751133 | - | 489 | WP_039022338.1 | DUF5983 family protein | - |
| IGI31_RS13370 (2751130) | 2751130..2751507 | - | 378 | WP_000854808.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| IGI31_RS13375 (2751596) | 2751596..2751964 | - | 369 | WP_214461210.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| IGI31_RS13380 (2752014) | 2752014..2752658 | - | 645 | WP_039025881.1 | hypothetical protein | - |
| IGI31_RS13385 (2752673) | 2752673..2752894 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| IGI31_RS13390 (2752963) | 2752963..2753439 | - | 477 | WP_001186742.1 | RadC family protein | - |
| IGI31_RS13395 (2753454) | 2753454..2753939 | - | 486 | WP_000214316.1 | antirestriction protein | - |
| IGI31_RS13400 (2754030) | 2754030..2754848 | - | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13909.93 Da Isoelectric Point: 7.9085
>T203636 WP_000854808.1 NZ_CP075465:c2751507-2751130 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T203636 NZ_CP100204:c1740337-1739840 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13860.74 Da Isoelectric Point: 7.3217
>AT203636 WP_214461210.1 NZ_CP075465:c2751964-2751596 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHIVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHIVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN
Download Length: 369 bp
>AT203636 NZ_CP100204:c1740615-1740334 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|