Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4756190..4756706 Replicon chromosome
Accession NZ_CP075452
Organism Klebsiella pneumoniae strain RGF20-1

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag KI738_RS23205 Protein ID WP_004192395.1
Coordinates 4756190..4756474 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag KI738_RS23210 Protein ID WP_004192397.1
Coordinates 4756464..4756706 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI738_RS23180 (4751607) 4751607..4751870 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KI738_RS23185 (4752000) 4752000..4752173 + 174 WP_002886906.1 hypothetical protein -
KI738_RS23190 (4752176) 4752176..4752919 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KI738_RS23195 (4753276) 4753276..4755414 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KI738_RS23200 (4755722) 4755722..4756186 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KI738_RS23205 (4756190) 4756190..4756474 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI738_RS23210 (4756464) 4756464..4756706 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KI738_RS23215 (4756784) 4756784..4758694 - 1911 WP_004152270.1 PRD domain-containing protein -
KI738_RS23220 (4758717) 4758717..4759871 - 1155 WP_004178372.1 lactonase family protein -
KI738_RS23225 (4759938) 4759938..4760678 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T203585 WP_004192395.1 NZ_CP075452:c4756474-4756190 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T203585 NZ_CP100146:c125215-124865 [Burkholderia glumae]
ATGGTGAAGCGGGTCAAGTTCGAGCGAGGCGATATCGTGCGAGTGAGTCTGAGTCCGACGGTCGGCCGTGAGCAGCAAGG
AGATTTTCGTCCCGCGCTTGTGCTCTCTCCGGCGGCGTTTAACGCGCTGGGTGTGGCGCTCGTTGCCCCGATTACCCAGG
GCGGTGAATTCGCCCGCTTTGCAGGTTTTGCGGTTCCGCTCTCCGGTTCGGGGACGGAGACACAGGGAGTGGCACTGGTG
AACATGGTACGCATGCTCGACTTGGAAGGACGCGGCGCACGCAAGATCGAACGCGCGCCCGTCGAAGTGGTAGAGGATGC
CCTGGCCCGTCTTCAAACGATTATTGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT203585 WP_004192397.1 NZ_CP075452:c4756706-4756464 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT203585 NZ_CP100146:c125460-125209 [Burkholderia glumae]
ATGGAACTAAAGATTCAGAAATGGGGCAATAGCGCGGCGGTGCGTTTGCCGAGCGTATTGCTCGAACAGATCAACGCATC
GGTCGGCGGTTCGCTGAACGCGGACGTGCGGCCGGATGGGGTGCTACTGACCCCGGCCCGGCGGAAGTATGCGCTGGATG
ATCTCGTGGCTCAGTGCGACACGAAGGCGCCTGTTCCGGCCGACATGGCAGCCTGGGGCGAGATCAAGCCGGTGGGACGT
GAAGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References