Detailed information of TA system TA203584

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4675175..4675854
• Replicon: chromosome
• Accession: NZ_CP075452
• Organism: Klebsiella pneumoniae strain RGF20-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KI738_RS22860
• Protein ID: WP_065812068.1
• Coordinates: 4675175..4675495 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KI738_RS22865
• Protein ID: WP_063444359.1
• Coordinates: 4675531..4675854 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI738_RS22830 (4670469)	4670469..4670735	+	267	WP_004178415.1	hypothetical protein	-
KI738_RS22835 (4670735)	4670735..4671407	+	673	Protein_4491	DUF4400 domain-containing protein	-
KI738_RS22840 (4671418)	4671418..4672302	+	885	WP_004192285.1	RES domain-containing protein	-
KI738_RS22845 (4672501)	4672501..4672689	-	189	Protein_4493	transposase	-
KI738_RS22850 (4672706)	4672706..4673817	-	1112	Protein_4494	IS3 family transposase	-
KI738_RS22855 (4674228)	4674228..4675061	-	834	WP_041162402.1	DUF4942 domain-containing protein	-
KI738_RS22860 (4675175)	4675175..4675495	-	321	WP_065812068.1	TA system toxin CbtA family protein	Toxin
KI738_RS22865 (4675531)	4675531..4675854	-	324	WP_063444359.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KI738_RS22870 (4675867)	4675867..4676337	-	471	WP_063444360.1	DNA repair protein RadC	-
KI738_RS22875 (4676408)	4676408..4677229	-	822	WP_045341626.1	DUF932 domain-containing protein	-
KI738_RS22880 (4677339)	4677339..4677800	-	462	WP_063444373.1	IrmA family protein	-
KI738_RS22885 (4677932)	4677932..4678579	-	648	WP_063444361.1	hypothetical protein	-
KI738_RS22890 (4678585)	4678585..4679286	-	702	WP_065812067.1	WYL domain-containing protein	-
KI738_RS22895 (4679499)	4679499..4680374	-	876	WP_065812066.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4664580..4699557	34977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12008.68 Da
• Isoelectric Point: 6.0604

>T203584 WP_065812068.1 NZ_CP075452:c4675495-4675175 [Klebsiella pneumoniae]
MYISAVPATVPVSSRLSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDAAIKEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T203584 NZ_CP100145:c1694520-1694023 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12082.77 Da
• Isoelectric Point: 6.6314

>AT203584 WP_063444359.1 NZ_CP075452:c4675854-4675531 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFSPIHLQKLDQAFPLFIEQLENMLRVGELNPHQQYHVT
IQLASLTCIADTRGSCGYVYISIYPTQ

Nucleotide

• Length: 324 bp

>AT203584 NZ_CP100145:c1694798-1694517 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA