Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4338120..4338715 Replicon chromosome
Accession NZ_CP075374
Organism Escherichia coli strain no107

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag KIB02_RS20980 Protein ID WP_000239576.1
Coordinates 4338120..4338470 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KIB02_RS20985 Protein ID WP_001223208.1
Coordinates 4338464..4338715 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIB02_RS20960 (4333396) 4333396..4334418 - 1023 WP_001296689.1 ABC transporter permease -
KIB02_RS20965 (4334432) 4334432..4335934 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
KIB02_RS20970 (4336244) 4336244..4337200 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KIB02_RS20975 (4337510) 4337510..4338040 + 531 WP_000055075.1 inorganic diphosphatase -
KIB02_RS20980 (4338120) 4338120..4338470 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
KIB02_RS20985 (4338464) 4338464..4338715 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KIB02_RS20990 (4338927) 4338927..4339268 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KIB02_RS20995 (4339271) 4339271..4343050 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T203553 WP_000239576.1 NZ_CP075374:c4338470-4338120 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T203553 NZ_CP100120:1935387-1935489 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT203553 WP_001223208.1 NZ_CP075374:c4338715-4338464 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT203553 NZ_CP100120:c1935496-1935351 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References