Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 50453..51286 Replicon chromosome
Accession NZ_CP075374
Organism Escherichia coli strain no107

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KIB02_RS00260 Protein ID WP_213833149.1
Coordinates 50453..50827 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag KIB02_RS00265 Protein ID WP_001540478.1
Coordinates 50918..51286 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIB02_RS00235 (46155) 46155..47338 - 1184 Protein_45 sugar efflux transporter -
KIB02_RS00240 (47767) 47767..47895 - 129 Protein_46 RhuM family protein -
KIB02_RS00245 (48222) 48222..49063 - 842 Protein_47 DUF4942 domain-containing protein -
KIB02_RS00250 (49141) 49141..49329 - 189 WP_042017791.1 DUF957 domain-containing protein -
KIB02_RS00255 (50111) 50111..50311 - 201 WP_198447747.1 hypothetical protein -
KIB02_RS26715 (50297) 50297..50456 - 160 Protein_50 DUF5983 family protein -
KIB02_RS00260 (50453) 50453..50827 - 375 WP_213833149.1 TA system toxin CbtA family protein Toxin
KIB02_RS00265 (50918) 50918..51286 - 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KIB02_RS00270 (51463) 51463..51684 - 222 WP_000692300.1 DUF987 domain-containing protein -
KIB02_RS00275 (51753) 51753..52229 - 477 WP_032408846.1 RadC family protein -
KIB02_RS00280 (52244) 52244..52729 - 486 WP_001559912.1 antirestriction protein -
KIB02_RS00285 (52821) 52821..53639 - 819 WP_001559911.1 DUF932 domain-containing protein -
KIB02_RS00290 (53739) 53739..53972 - 234 WP_001119729.1 DUF905 family protein -
KIB02_RS00295 (54051) 54051..54506 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14017.95 Da        Isoelectric Point: 7.2911

>T203534 WP_213833149.1 NZ_CP075374:c50827-50453 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T203534 NZ_CP100114:2036879-2036981 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT203534 WP_001540478.1 NZ_CP075374:c51286-50918 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT203534 NZ_CP100114:c2036988-2036843 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References