203533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 146651..148274 Replicon plasmid unnamed
Accession NZ_CP075373
Organism Salmonella enterica strain no75

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag KH432_RS25615 Protein ID WP_000088046.1
Coordinates 146651..147976 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag KH432_RS25620 Protein ID WP_024136327.1
Coordinates 147981..148274 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH432_RS25585 (KH432_25585) 143322..143621 - 300 WP_001572440.1 hypothetical protein -
KH432_RS25590 (KH432_25590) 143676..143911 - 236 Protein_164 type I restriction-modification system subunit M N-terminal domain-containing protein -
KH432_RS25595 (KH432_25595) 144365..144790 - 426 WP_001043843.1 hypothetical protein -
KH432_RS25600 (KH432_25600) 145044..145859 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
KH432_RS25605 (KH432_25605) 145872..146282 - 411 WP_000985911.1 hypothetical protein -
KH432_RS25610 (KH432_25610) 146384..146590 - 207 WP_000134171.1 hypothetical protein -
KH432_RS25615 (KH432_25615) 146651..147976 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
KH432_RS25620 (KH432_25620) 147981..148274 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
KH432_RS25625 (KH432_25625) 148878..149270 - 393 WP_000341066.1 hypothetical protein -
KH432_RS25630 (KH432_25630) 149643..149984 + 342 WP_001151575.1 hypothetical protein -
KH432_RS25635 (KH432_25635) 150076..150267 + 192 WP_000398480.1 hypothetical protein -
KH432_RS25640 (KH432_25640) 150317..150598 + 282 WP_000077926.1 hypothetical protein -
KH432_RS25645 (KH432_25645) 151032..152010 + 979 Protein_175 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxB / oqxA / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / dfrA12 / sul1 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / blaCTX-M-14 / fosA3 / mcr-1.1 - 1..250232 250232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T203533 WP_000088046.1 NZ_CP075373:c147976-146651 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T203533 NZ_CP100114:855872-856282 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT203533 WP_024136327.1 NZ_CP075373:c148274-147981 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT203533 NZ_CP100114:855625-855891 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References