Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4271297..4271813 Replicon chromosome
Accession NZ_CP075372
Organism Salmonella enterica strain no75

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag KH432_RS20845 Protein ID WP_000220578.1
Coordinates 4271297..4271581 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KH432_RS20850 Protein ID WP_000212724.1
Coordinates 4271571..4271813 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH432_RS20830 (4266509) 4266509..4268161 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
KH432_RS20835 (4268570) 4268570..4270708 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KH432_RS20840 (4270829) 4270829..4271293 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KH432_RS20845 (4271297) 4271297..4271581 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KH432_RS20850 (4271571) 4271571..4271813 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KH432_RS20855 (4271891) 4271891..4273804 - 1914 WP_001212137.1 BglG family transcription antiterminator -
KH432_RS20860 (4273821) 4273821..4274561 - 741 WP_000779263.1 KDGP aldolase family protein -
KH432_RS20865 (4274558) 4274558..4275676 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KH432_RS20870 (4275660) 4275660..4276793 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T203529 WP_000220578.1 NZ_CP075372:c4271581-4271297 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T203529 NZ_CP100111:181297-181713 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT203529 WP_000212724.1 NZ_CP075372:c4271813-4271571 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT203529 NZ_CP100111:181070-181300 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References