Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1731944..1732605 Replicon chromosome
Accession NZ_CP075371
Organism Nocardioides aquaticus strain KCTC 9944

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ENKNEFLB_RS08345 Protein ID WP_246535909.1
Coordinates 1731944..1732300 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ENKNEFLB_RS08350 Protein ID WP_214058765.1
Coordinates 1732357..1732605 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENKNEFLB_RS08325 (ENKNEFLB_01667) 1727080..1727595 + 516 WP_214058761.1 TadE family protein -
ENKNEFLB_RS08330 (ENKNEFLB_01668) 1727802..1728167 + 366 WP_214058762.1 hypothetical protein -
ENKNEFLB_RS08335 (ENKNEFLB_01669) 1728276..1731605 + 3330 WP_214058763.1 LysM peptidoglycan-binding domain-containing protein -
ENKNEFLB_RS08340 (ENKNEFLB_01670) 1731621..1731908 + 288 WP_214058764.1 hypothetical protein -
ENKNEFLB_RS08345 (ENKNEFLB_01671) 1731944..1732300 - 357 WP_246535909.1 type II toxin-antitoxin system VapC family toxin Toxin
ENKNEFLB_RS08350 1732357..1732605 - 249 WP_214058765.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ENKNEFLB_RS08355 (ENKNEFLB_01672) 1732860..1733810 + 951 WP_214058766.1 hypothetical protein -
ENKNEFLB_RS08360 (ENKNEFLB_01673) 1733871..1734203 + 333 WP_214058767.1 hypothetical protein -
ENKNEFLB_RS08365 (ENKNEFLB_01674) 1734461..1735225 + 765 WP_214058768.1 hypothetical protein -
ENKNEFLB_RS08370 (ENKNEFLB_01675) 1735304..1735588 + 285 WP_214059385.1 hypothetical protein -
ENKNEFLB_RS08375 (ENKNEFLB_01676) 1735611..1736570 + 960 WP_214058769.1 hypothetical protein -
ENKNEFLB_RS08380 (ENKNEFLB_01677) 1736567..1737445 + 879 WP_214058770.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1595460..1804700 209240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-102)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12508.42 Da        Isoelectric Point: 6.7260

>T203508 WP_246535909.1 NZ_CP075371:c1732300-1731944 [Nocardioides aquaticus]
VVIDEGASPIPGVLAISAVTLAELHFGVLVAKTTEVRAERLRRLSVLQQRFDALPVDDAVAASYGRLSAAVVDAGRRPRG
RVMDLLIAATAHAHGARLYTRNPVDFAGLEELVDVVGV

Download         Length: 357 bp

>T203508 NZ_CP100106:c4856137-4855853 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9358.50 Da        Isoelectric Point: 4.4992

>AT203508 WP_214058765.1 NZ_CP075371:c1732605-1732357 [Nocardioides aquaticus]
MTTVGLRELRQDASELVRRVEAGEEITISVSGRPSAVLVPVRPTRWRTWREVEDLFRGPADPDWAQDRALVDDELCDPWA
GR

Download         Length: 249 bp

>AT203508 NZ_CP100106:c4856369-4856127 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References