203505

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1..21354 Replicon plasmid pPB17_4
Accession NZ_CP075352
Organism Pseudochrobactrum algeriensis strain C150915_17

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag KHQ08_RS18355 Protein ID WP_213595987.1
Coordinates 21354..20 (+) Length -7111 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag KHQ08_RS18360 Protein ID WP_080921082.1
Coordinates 1..336 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHQ08_RS18360 (KHQ08_18360) 1..336 + 336 WP_080921082.1 helix-turn-helix transcriptional regulator Antitoxin
KHQ08_RS18365 (KHQ08_18365) 336..554 + 219 WP_213595989.1 hypothetical protein -
KHQ08_RS18370 (KHQ08_18370) 678..1067 - 390 WP_213595991.1 hypothetical protein -
KHQ08_RS18375 (KHQ08_18375) 1079..2755 - 1677 WP_213595992.1 type IV secretory system conjugative DNA transfer family protein -
KHQ08_RS18380 (KHQ08_18380) 2752..3057 - 306 WP_213596001.1 mobilization protein -
KHQ08_RS18385 (KHQ08_18385) 3328..7131 + 3804 WP_213596004.1 Ti-type conjugative transfer relaxase TraA -
KHQ08_RS18390 (KHQ08_18390) 7143..7895 + 753 WP_213596006.1 DUF6118 family protein -
KHQ08_RS18395 (KHQ08_18395) 7904..9367 - 1464 WP_213596008.1 NAD-dependent succinate-semialdehyde dehydrogenase -
KHQ08_RS18400 (KHQ08_18400) 9532..10311 + 780 WP_272491704.1 IclR family transcriptional regulator -
KHQ08_RS18405 (KHQ08_18405) 10378..11124 + 747 WP_213630906.1 acyl-CoA dehydrogenase family protein -
KHQ08_RS18410 (KHQ08_18410) 11034..11840 + 807 WP_213906500.1 acyl-CoA dehydrogenase family protein -
KHQ08_RS18415 (KHQ08_18415) 11923..12831 + 909 WP_213596014.1 alpha/beta hydrolase -
KHQ08_RS18420 (KHQ08_18420) 12957..13556 + 600 WP_080921075.1 recombinase family protein -
KHQ08_RS18425 (KHQ08_18425) 13781..14173 - 393 WP_109614750.1 hypothetical protein -
KHQ08_RS18430 (KHQ08_18430) 14324..14932 + 609 WP_056103234.1 recombinase family protein -
KHQ08_RS18435 (KHQ08_18435) 14941..17942 + 3002 Protein_16 Tn3 family transposase -
KHQ08_RS18440 (KHQ08_18440) 18032..18241 + 210 WP_025031070.1 ribbon-helix-helix protein, CopG family -
KHQ08_RS18445 (KHQ08_18445) 18434..19315 + 882 WP_080921086.1 helix-turn-helix domain-containing protein -
KHQ08_RS18450 (KHQ08_18450) 19558..20211 + 654 WP_213596016.1 SprT-like domain-containing protein -
KHQ08_RS18455 (KHQ08_18455) 20290..20949 + 660 WP_080921084.1 ParA family protein -
KHQ08_RS18460 (KHQ08_18460) 20946..21266 + 321 WP_213596018.1 chromosome partitioning protein ParB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..21711 21711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: -7111 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T203505 WP_213595987.1 NZ_CP075352:21354-20 [Pseudochrobactrum algeriensis]

Download         Length: -21333 bp

>T203505 NZ_CP100106:c3984675-3984358 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12141.19 Da        Isoelectric Point: 9.0961

>AT203505 WP_080921082.1 NZ_CP075352:1-336 [Pseudochrobactrum algeriensis]
MRTRIVNGVEVTTSSGNVFADLGLPDAEKLKMKSGLMIEITKAVRRLDLTQEEAGRRMGLPQPKVSALLRGDFTNLSERK
LMECLNRLGYDIEITVKPAADAVGHMTLAVA

Download         Length: 336 bp

>AT203505 NZ_CP100106:c3984365-3984078 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References