Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2528257..2528821 Replicon chromosome
Accession NZ_CP075343
Organism Streptomyces sp. EMB24

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KIH30_RS11320 Protein ID WP_102640794.1
Coordinates 2528257..2528604 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KIH30_RS11325 Protein ID WP_102640795.1
Coordinates 2528591..2528821 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH30_RS11305 2525472..2526314 - 843 WP_199208621.1 hypothetical protein -
KIH30_RS11310 2526316..2526849 - 534 WP_102640792.1 sigma-70 family RNA polymerase sigma factor -
KIH30_RS11315 2527183..2528199 + 1017 WP_199208620.1 aspartate-semialdehyde dehydrogenase -
KIH30_RS11320 2528257..2528604 - 348 WP_102640794.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KIH30_RS11325 2528591..2528821 - 231 WP_102640795.1 ribbon-helix-helix domain-containing protein Antitoxin
KIH30_RS11330 2529015..2531621 + 2607 WP_268219859.1 aminopeptidase N -
KIH30_RS11335 2531677..2532027 - 351 Protein_2241 TetR/AcrR family transcriptional regulator -
KIH30_RS11340 2532078..2532275 - 198 WP_268219860.1 DUF397 domain-containing protein -
KIH30_RS11345 2532284..2533135 - 852 WP_268219861.1 helix-turn-helix transcriptional regulator -
KIH30_RS11350 2533338..2533742 + 405 Protein_2244 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12667.55 Da        Isoelectric Point: 10.9360

>T203465 WP_102640794.1 NZ_CP075343:c2528604-2528257 [Streptomyces sp. EMB24]
MRRGDIYMVDLEPVRGSEANKVRPAVIVSNDGANASVERHGRGVVSVVPLTSNTTRVLSFQVFLSADESRLPKDSKAQCE
QVRAVAPDRLLHRVGAVPRQRMADIDVALRRHLAL

Download         Length: 348 bp

>T203465 NZ_CP100095:181296-181712 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8345.04 Da        Isoelectric Point: 3.7832

>AT203465 WP_102640795.1 NZ_CP075343:c2528821-2528591 [Streptomyces sp. EMB24]
MKISVSLPQEDVAFVDEYAARTDAESRSAVIHAAIELLRQAQLVQEYTEAFAEWDAGEDAAAWDRTSGDGVADEAW

Download         Length: 231 bp

>AT203465 NZ_CP100095:181069-181299 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References