Detailed information of TA system TA203464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2116842..2117409
• Replicon: chromosome
• Accession: NZ_CP075343
• Organism: Streptomyces sp. EMB24

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KIH30_RS09515
• Protein ID: WP_268219719.1
• Coordinates: 2116842..2117123 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KIH30_RS09520
• Protein ID: WP_268219720.1
• Coordinates: 2117128..2117409 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KIH30_RS09495	2113361..2114146	+	786	WP_122217059.1	SDR family oxidoreductase	-
KIH30_RS09500	2114424..2115428	-	1005	WP_268219717.1	aldo/keto reductase	-
KIH30_RS09510	2115921..2116652	-	732	WP_268219718.1	hypothetical protein	-
KIH30_RS09515	2116842..2117123	-	282	WP_268219719.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KIH30_RS09520	2117128..2117409	-	282	WP_268219720.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KIH30_RS09525	2117411..2117962	-	552	WP_251097645.1	ATP-binding protein	-
KIH30_RS09530	2118110..2119030	+	921	WP_268221735.1	helix-turn-helix transcriptional regulator	-
KIH30_RS09535	2119027..2119242	+	216	WP_086698735.1	DUF397 domain-containing protein	-
KIH30_RS09540	2119434..2120660	+	1227	WP_268219721.1	cytochrome P450	-
KIH30_RS09545	2120781..2122058	-	1278	WP_268219722.1	cytochrome P450	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10731.48 Da
• Isoelectric Point: 10.2363

>T203464 WP_268219719.1 NZ_CP075343:c2117123-2116842 [Streptomyces sp. EMB24]
MGCVTRFTPHAQRDMLKIPRPDALRILYRFTELQKAMDAGDTAAFDIKALQGHSARWRLRVGDYRVVYTVEDGRLIVWAL
ALGNRLDVYRQVP

Nucleotide

• Length: 282 bp

>T203464 NZ_CP100095:157427-157918 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10608.85 Da
• Isoelectric Point: 4.2559

>AT203464 WP_268219720.1 NZ_CP075343:c2117409-2117128 [Streptomyces sp. EMB24]
MSEPVIESMAEVRGHLADVIDRARREETPTIITRRGKQEAVVIDIEEYQRLRRIAENAEEAWLNRLADEAESEGLEGAVS
LEEMAAMLRTDRD

Nucleotide

• Length: 282 bp

>AT203464 NZ_CP100095:157173-157439 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA