Detailed information of TA system TA203462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 1424537..1425043
• Replicon: chromosome
• Accession: NZ_CP075339
• Organism: Leucobacter aridicollis strain J1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI794_RS06360
• Protein ID: WP_119283013.1
• Coordinates: 1424537..1424791 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KI794_RS06365
• Protein ID: WP_119283014.1
• Coordinates: 1424792..1425043 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI794_RS06330 (KI794_06335)	1421005..1421391	-	387	WP_119283007.1	thioredoxin	-
KI794_RS06335 (KI794_06340)	1421427..1421615	-	189	WP_119283008.1	hypothetical protein	-
KI794_RS06340 (KI794_06345)	1421743..1422078	+	336	WP_119283009.1	metal-sensitive transcriptional regulator	-
KI794_RS06345 (KI794_06350)	1422155..1422616	+	462	WP_119283010.1	SRPBCC domain-containing protein	-
KI794_RS06350 (KI794_06355)	1422627..1423439	-	813	WP_119283011.1	ABC transporter permease subunit	-
KI794_RS06355 (KI794_06360)	1423436..1424407	-	972	WP_255809530.1	ABC transporter ATP-binding protein	-
KI794_RS06360 (KI794_06365)	1424537..1424791	-	255	WP_119283013.1	Txe/YoeB family addiction module toxin	Toxin
KI794_RS06365 (KI794_06370)	1424792..1425043	-	252	WP_119283014.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KI794_RS06370	1425190..1425766	+	577	Protein_1257	transposase	-
KI794_RS06375 (KI794_06385)	1426002..1426580	-	579	WP_119283017.1	MarR family transcriptional regulator	-
KI794_RS06380 (KI794_06390)	1426743..1427678	+	936	WP_255809531.1	transporter substrate-binding domain-containing protein	-
KI794_RS06385 (KI794_06395)	1427678..1428586	+	909	WP_119283019.1	amino acid ABC transporter permease	-
KI794_RS06390 (KI794_06400)	1428583..1429380	+	798	WP_119283020.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10015.52 Da
• Isoelectric Point: 9.4024

>T203462 WP_119283013.1 NZ_CP075339:c1424791-1424537 [Leucobacter aridicollis]
MRLAWDRSAWEDYLYWQATDRRTMKRINALIDACLRTPFEGIGKPEQLKYGAQGAWSRRITAEHRLVYLVEGDLVIILQA
RYHY

Nucleotide

• Length: 255 bp

>T203462 NZ_CP100094:c5324594-5324211 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9360.37 Da
• Isoelectric Point: 5.7134

>AT203462 WP_119283014.1 NZ_CP075339:c1425043-1424792 [Leucobacter aridicollis]
VSISASEARRSLFPLIERVNADREAVEIVSRRGNAVLMPADEYAAWQETAYLFASPANARRLLDSYERARSGHTEDHKLD
RGE

Nucleotide

• Length: 252 bp

>AT203462 NZ_CP100094:c5324836-5324594 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA