Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5122871..5123538 Replicon chromosome
Accession NZ_CP075325
Organism Xanthomonas citri pv. citri strain GD82

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag KJA71_RS22075 Protein ID WP_005916679.1
Coordinates 5123122..5123538 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag KJA71_RS22070 Protein ID WP_005916676.1
Coordinates 5122871..5123125 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA71_RS22045 (KJA71_22045) 5119033..5119212 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
KJA71_RS22050 (KJA71_22050) 5119369..5120634 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
KJA71_RS22055 (KJA71_22055) 5120660..5121187 - 528 WP_005916668.1 hypothetical protein -
KJA71_RS22060 (KJA71_22060) 5121426..5121632 + 207 WP_003489327.1 hypothetical protein -
KJA71_RS22065 (KJA71_22065) 5121619..5122725 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
KJA71_RS22070 (KJA71_22070) 5122871..5123125 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
KJA71_RS22075 (KJA71_22075) 5123122..5123538 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
KJA71_RS22080 (KJA71_22080) 5123660..5123932 - 273 WP_125459513.1 hypothetical protein -
KJA71_RS22085 (KJA71_22085) 5123991..5124203 - 213 WP_015472901.1 hypothetical protein -
KJA71_RS22090 (KJA71_22090) 5124460..5126079 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
KJA71_RS22095 (KJA71_22095) 5126183..5126581 - 399 WP_004429277.1 DUF2384 domain-containing protein -
KJA71_RS22100 (KJA71_22100) 5126897..5127328 + 432 WP_005922907.1 hypothetical protein -
KJA71_RS22105 (KJA71_22105) 5127357..5127587 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T203458 WP_005916679.1 NZ_CP075325:5123122-5123538 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T203458 NZ_CP100094:4109387-4109605 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT203458 WP_005916676.1 NZ_CP075325:5122871-5123125 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT203458 NZ_CP100094:4108986-4109360 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References