Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4724893..4725254 Replicon chromosome
Accession NZ_CP075325
Organism Xanthomonas citri pv. citri strain GD82

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag KJA71_RS20505 Protein ID WP_005914328.1
Coordinates 4724893..4725027 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag KJA71_RS20510 Protein ID WP_003486606.1
Coordinates 4725102..4725254 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA71_RS20485 (KJA71_20485) 4720031..4721722 - 1692 WP_015471463.1 M28 family metallopeptidase -
KJA71_RS20490 (KJA71_20490) 4721914..4722858 - 945 WP_015463704.1 MBL fold metallo-hydrolase -
KJA71_RS20495 (KJA71_20495) 4722987..4724276 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
KJA71_RS20500 (KJA71_20500) 4724457..4724666 - 210 WP_003486601.1 CsbD family protein -
KJA71_RS20505 (KJA71_20505) 4724893..4725027 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
KJA71_RS20510 (KJA71_20510) 4725102..4725254 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
KJA71_RS20515 (KJA71_20515) 4725361..4726284 - 924 WP_005927745.1 arginase -
KJA71_RS20520 (KJA71_20520) 4726605..4727057 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
KJA71_RS20525 (KJA71_20525) 4727121..4727480 + 360 WP_003486613.1 hypothetical protein -
KJA71_RS20530 (KJA71_20530) 4727577..4728494 + 918 WP_011052673.1 hypothetical protein -
KJA71_RS20535 (KJA71_20535) 4728491..4729033 + 543 WP_003486615.1 GTPase -
KJA71_RS20540 (KJA71_20540) 4729471..4730154 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T203457 WP_005914328.1 NZ_CP075325:c4725027-4724893 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T203457 NZ_CP100094:c3984345-3984028 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT203457 WP_003486606.1 NZ_CP075325:c4725254-4725102 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT203457 NZ_CP100094:c3984035-3983748 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References