Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 480180..480833 Replicon chromosome
Accession NZ_CP075323
Organism Acinetobacter sp. BHS4

Toxin (Protein)


Gene name cptA Uniprot ID F0KQ02
Locus tag KIP84_RS02350 Protein ID WP_014207739.1
Coordinates 480444..480833 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag KIP84_RS02345 Protein ID WP_002117064.1
Coordinates 480180..480437 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIP84_RS02325 (KIP84_02325) 475693..476700 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
KIP84_RS02330 (KIP84_02330) 476719..477096 + 378 WP_002049717.1 50S ribosomal protein L17 -
KIP84_RS02335 (KIP84_02335) 477278..478768 + 1491 WP_213689249.1 NAD(P)/FAD-dependent oxidoreductase -
KIP84_RS02340 (KIP84_02340) 478819..479991 - 1173 WP_213689250.1 acyl-CoA dehydrogenase family protein -
KIP84_RS02345 (KIP84_02345) 480180..480437 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
KIP84_RS02350 (KIP84_02350) 480444..480833 + 390 WP_014207739.1 hypothetical protein Toxin
KIP84_RS02355 (KIP84_02355) 481604..482692 + 1089 WP_014207738.1 hypothetical protein -
KIP84_RS02360 (KIP84_02360) 482777..483352 + 576 WP_005078319.1 rhombosortase -
KIP84_RS02365 (KIP84_02365) 483532..485727 + 2196 WP_063097833.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15549.66 Da        Isoelectric Point: 8.7390

>T203451 WP_014207739.1 NZ_CP075323:480444-480833 [Acinetobacter sp. BHS4]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVTYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T203451 NZ_CP100092:5256-5522 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT203451 WP_002117064.1 NZ_CP075323:480180-480437 [Acinetobacter sp. BHS4]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT203451 NZ_CP100092:5048-5272 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2PTH0

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References