Detailed information of TA system TA203450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1065356..1066007
• Replicon: chromosome
• Accession: NZ_CP075321
• Organism: Acinetobacter baumannii strain DD520

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: KJA61_RS05250
• Protein ID: WP_000838146.1
• Coordinates: 1065356..1065538 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: KJA61_RS05255
• Protein ID: WP_000966689.1
• Coordinates: 1065603..1066007 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA61_RS05205 (KJA61_05205)	1060613..1061278	+	666	WP_000767881.1	Ish1 domain-containing protein	-
KJA61_RS05210 (KJA61_05210)	1061283..1061672	+	390	WP_000008492.1	hypothetical protein	-
KJA61_RS05215 (KJA61_05215)	1061674..1062042	+	369	WP_000524231.1	hypothetical protein	-
KJA61_RS05220 (KJA61_05220)	1062051..1062455	+	405	WP_000248324.1	hypothetical protein	-
KJA61_RS05225 (KJA61_05225)	1062427..1062795	+	369	WP_000539752.1	hypothetical protein	-
KJA61_RS05230 (KJA61_05230)	1062797..1063195	+	399	WP_001132270.1	hypothetical protein	-
KJA61_RS05235 (KJA61_05235)	1063197..1063409	+	213	WP_000121166.1	hypothetical protein	-
KJA61_RS05240 (KJA61_05240)	1063517..1064446	+	930	WP_000094300.1	phage tail tube protein	-
KJA61_RS05245 (KJA61_05245)	1064491..1065024	+	534	WP_001185622.1	hypothetical protein	-
KJA61_RS05250 (KJA61_05250)	1065356..1065538	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
KJA61_RS05255 (KJA61_05255)	1065603..1066007	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KJA61_RS05260 (KJA61_05260)	1066088..1066489	+	402	WP_000720591.1	hypothetical protein	-
KJA61_RS05265 (KJA61_05265)	1066550..1070515	+	3966	WP_000191304.1	tape measure protein	-
KJA61_RS05270 (KJA61_05270)	1070633..1070974	+	342	WP_001281459.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1034963..1089578	54615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T203450 WP_000838146.1 NZ_CP075321:1065356-1065538 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T203450 NZ_CP100091:c2985-2671 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT203450 WP_000966689.1 NZ_CP075321:1065603-1066007 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT203450 NZ_CP100091:c3251-2973 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8