Detailed information of TA system TA203449

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 456066..456719
• Replicon: chromosome
• Accession: NZ_CP075321
• Organism: Acinetobacter baumannii strain DD520

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KJA61_RS02245
• Protein ID: WP_000607077.1
• Coordinates: 456330..456719 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: KJA61_RS02240
• Protein ID: WP_001288210.1
• Coordinates: 456066..456323 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJA61_RS02220 (KJA61_02220)	451582..452589	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
KJA61_RS02225 (KJA61_02225)	452608..452985	+	378	WP_001216380.1	50S ribosomal protein L17	-
KJA61_RS02230 (KJA61_02230)	453167..454657	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
KJA61_RS02235 (KJA61_02235)	454706..455878	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
KJA61_RS02240 (KJA61_02240)	456066..456323	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
KJA61_RS02245 (KJA61_02245)	456330..456719	+	390	WP_000607077.1	membrane protein	Toxin
KJA61_RS02250 (KJA61_02250)	457489..458574	+	1086	WP_000049106.1	hypothetical protein	-
KJA61_RS02255 (KJA61_02255)	458652..459218	+	567	WP_000651538.1	rhombosortase	-
KJA61_RS02260 (KJA61_02260)	459406..461601	+	2196	WP_038350236.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T203449 WP_000607077.1 NZ_CP075321:456330-456719 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T203449 NZ_CP100089:128401-128883 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT203449 WP_001288210.1 NZ_CP075321:456066-456323 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT203449 NZ_CP100089:128147-128413 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7