Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4936718..4937234 Replicon chromosome
Accession NZ_CP075316
Organism Klebsiella pneumoniae strain DD521

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KJA60_RS23735 Protein ID WP_004178374.1
Coordinates 4936718..4937002 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KJA60_RS23740 Protein ID WP_002886901.1
Coordinates 4936992..4937234 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJA60_RS23710 (4932202) 4932202..4932465 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
KJA60_RS23715 (4932595) 4932595..4932768 + 174 WP_032408826.1 hypothetical protein -
KJA60_RS23720 (4932771) 4932771..4933514 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KJA60_RS23725 (4933871) 4933871..4936009 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KJA60_RS23730 (4936250) 4936250..4936714 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KJA60_RS23735 (4936718) 4936718..4937002 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KJA60_RS23740 (4936992) 4936992..4937234 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KJA60_RS23745 (4937312) 4937312..4939222 - 1911 WP_004178373.1 PRD domain-containing protein -
KJA60_RS23750 (4939245) 4939245..4940399 - 1155 WP_004178372.1 lactonase family protein -
KJA60_RS23755 (4940466) 4940466..4941206 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T203443 WP_004178374.1 NZ_CP075316:c4937002-4936718 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T203443 NZ_CP100087:4694048-4694266 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT203443 WP_002886901.1 NZ_CP075316:c4937234-4936992 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT203443 NZ_CP100087:4693647-4694021 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References