Detailed information of TA system TA020343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1095633..1096183
• Replicon: chromosome
• Accession: NC_002678
• Organism: Mesorhizobium loti MAFF303099

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MAFF_RS37510
• Protein ID: WP_010910061.1
• Coordinates: 1095887..1096183 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6M7TQI6
• Locus tag: MAFF_RS06370
• Protein ID: WP_027046965.1
• Coordinates: 1095633..1095887 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAFF_RS06345	1091350..1092198	-	849	WP_010910055.1	ABC transporter permease	-
MAFF_RS06350	1092185..1093006	-	822	WP_010910056.1	ABC transporter ATP-binding protein	-
MAFF_RS06355	1093019..1094023	-	1005	WP_010910057.1	ABC transporter substrate-binding protein	-
MAFF_RS06360	1094289..1094672	+	384	WP_010910058.1	RidA family protein	-
MAFF_RS06365	1094727..1095530	+	804	WP_010910059.1	creatininase family protein	-
MAFF_RS06370	1095633..1095887	+	255	WP_027046965.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MAFF_RS37510	1095887..1096183	+	297	WP_010910061.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MAFF_RS06380	1096208..1096717	-	510	WP_044547924.1	tyrosine phosphatase family protein	-
MAFF_RS06385	1096714..1097760	-	1047	WP_010910063.1	threonine-phosphate decarboxylase	-
MAFF_RS06390	1097759..1098733	+	975	WP_010910064.1	cobalamin biosynthesis protein CobD	-
MAFF_RS06395	1098730..1099344	-	615	WP_010910065.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
MAFF_RS06400	1099346..1099861	-	516	WP_010910066.1	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	-
MAFF_RS06405	1099854..1100669	-	816	WP_010910067.1	CbtA family protein	-
MAFF_RS06410	1100685..1100864	-	180	WP_044547928.1	CbtB-domain containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (6-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.79 Da
• Isoelectric Point: 6.3288

>T20343 WP_010910061.1 NC_002678:1095887-1096183 [Mesorhizobium japonicum MAFF 303099]
MGFRLSLAAEEDIIGIAEQGVRLFGAVQARQYHDELFAIFDLIAAGPRMARERLELSPPMRIHPFKAHLVVYRIEADGDV
FIVRVRHGHEDWANEGTR

Nucleotide

• Length: 297 bp

>T20343 NC_002678:1095887-1096183 [Mesorhizobium japonicum MAFF 303099]
ATGGGATTTCGCCTTTCTTTAGCCGCGGAAGAGGACATCATCGGTATTGCCGAGCAAGGGGTGCGCCTGTTCGGTGCTGT
GCAGGCCAGACAGTATCATGACGAGTTGTTCGCGATCTTTGACCTGATCGCTGCCGGTCCCCGAATGGCACGGGAGCGGC
TTGAATTGTCGCCACCAATGCGTATCCATCCCTTCAAGGCCCATCTTGTCGTCTACCGGATCGAAGCCGACGGCGACGTG
TTCATTGTCCGGGTACGCCACGGGCACGAAGATTGGGCGAATGAAGGCACTCGATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9347.38 Da
• Isoelectric Point: 6.3108

>AT20343 WP_027046965.1 NC_002678:1095633-1095887 [Mesorhizobium japonicum MAFF 303099]
MATMNVSLPDPMKDWVEAQTETGRYANASDYVRDLIRRDQERNDNIAAMQRFVDDGLKSGIGNRSRDALFTEAVKRAGKS
PGNG

Nucleotide

• Length: 255 bp

>AT20343 NC_002678:1095633-1095887 [Mesorhizobium japonicum MAFF 303099]
ATGGCAACAATGAACGTATCATTGCCTGATCCGATGAAGGATTGGGTTGAGGCGCAAACCGAAACGGGTCGCTACGCCAA
CGCGAGCGACTATGTGCGCGATTTGATCCGTCGGGATCAGGAGCGCAACGACAACATTGCCGCCATGCAGCGCTTTGTCG
ATGACGGATTGAAGAGTGGTATCGGCAATCGATCCAGGGACGCGCTTTTTACTGAGGCGGTCAAACGCGCTGGAAAGTCA
CCCGGCAACGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M7TQI6