Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4841881..4842397 Replicon chromosome
Accession NZ_CP075286
Organism Klebsiella pneumoniae strain YTF44-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KI725_RS24120 Protein ID WP_002886902.1
Coordinates 4841881..4842165 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KI725_RS24125 Protein ID WP_002886901.1
Coordinates 4842155..4842397 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI725_RS24095 (KI725_24095) 4837365..4837628 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KI725_RS24100 (KI725_24100) 4837758..4837931 + 174 WP_002886906.1 hypothetical protein -
KI725_RS24105 (KI725_24105) 4837934..4838677 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KI725_RS24110 (KI725_24110) 4839034..4841172 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KI725_RS24115 (KI725_24115) 4841413..4841877 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KI725_RS24120 (KI725_24120) 4841881..4842165 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI725_RS24125 (KI725_24125) 4842155..4842397 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KI725_RS24130 (KI725_24130) 4842475..4844385 - 1911 WP_004152270.1 PRD domain-containing protein -
KI725_RS24135 (KI725_24135) 4844408..4845562 - 1155 WP_002886900.1 lactonase family protein -
KI725_RS24140 (KI725_24140) 4845628..4846368 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T203420 WP_002886902.1 NZ_CP075286:c4842165-4841881 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T203420 NZ_CP100084:846844-847254 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT203420 WP_002886901.1 NZ_CP075286:c4842397-4842155 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT203420 NZ_CP100084:846597-846863 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References