Detailed information of TA system TA020342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 2513870..2514582
• Replicon: chromosome
• Accession: NC_002677
• Organism: Mycobacterium leprae TN

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: ML_RS10800
• Protein ID: WP_197492508.1
• Coordinates: 2513870..2514394 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: Q9CBE3
• Locus tag: ML_RS10805
• Protein ID: WP_010908719.1
• Coordinates: 2514412..2514582 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ML_RS10785	2510311..2510547	+	237	WP_049769854.1	hypothetical protein	-
ML_RS10790	2510862..2512335	+	1474	Protein_2075	carotenoid oxygenase family protein	-
ML_RS10795	2512539..2512973	-	435	WP_010908717.1	hypothetical protein	-
ML_RS10800	2513870..2514394	-	525	WP_197492508.1	SRPBCC family protein	Toxin
ML_RS10805	2514412..2514582	-	171	WP_010908719.1	antitoxin	Antitoxin
ML_RS10810	2514688..2516698	-	2011	Protein_2079	hypothetical protein	-
ML_RS10815	2516695..2517544	-	850	Protein_2080	hypothetical protein	-
ML_RS10820	2517649..2518576	-	928	Protein_2081	MBL fold metallo-hydrolase	-
ML_RS10825	2518770..2519513	-	744	WP_010908720.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-141)

Antitoxin

• Antitoxin Rv0909/MT0933 (2-50)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 18906.92 Da
• Isoelectric Point: 9.9666

>T20342 WP_197492508.1 NC_002677:c2514394-2513870 [Mycobacterium leprae TN]
MAKLTGSIDVPLPPNEAWMCASDLARFGEWLTIHRAWRSKLPEVVEKGTVIESYVEVKGMPNRIRWTVVRYKAPEAMTLN
GDGVGGVKVKLIAKVSPKDDGSVVSFDVHLGGSALFGPIGMIVAVALRTDIRESLQNFVTAFSRPEPGLIRSRALVVDQH
SRAVVEQRSASAGL

Nucleotide

• Length: 525 bp

>T20342 NC_002677:c2514394-2513870 [Mycobacterium leprae TN]
ATGGCGAAACTCACCGGATCTATCGACGTACCACTGCCACCGAATGAGGCCTGGATGTGTGCCTCCGATCTGGCCCGCTT
CGGTGAATGGCTAACGATTCACCGGGCGTGGCGCAGCAAGTTGCCTGAAGTGGTGGAGAAGGGCACGGTCATCGAGTCCT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAGATGGACGGTTGTGCGTTACAAAGCGCCTGAGGCCATGACGCTCAAC
GGCGACGGTGTTGGCGGTGTCAAGGTCAAGCTGATTGCTAAGGTTTCGCCTAAGGACGACGGCTCTGTCGTCAGCTTTGA
TGTGCATCTGGGTGGCTCCGCGCTGTTTGGACCGATAGGGATGATCGTCGCCGTTGCGCTGCGAACTGATATCCGCGAAT
CGTTACAGAACTTTGTCACGGCGTTCTCGCGACCGGAACCTGGCCTGATTAGGAGTCGGGCGCTCGTCGTTGACCAGCAT
AGTAGGGCCGTCGTCGAACAGCGGTCAGCATCGGCCGGGCTGTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6182.93 Da
• Isoelectric Point: 4.4883

>AT20342 WP_010908719.1 NC_002677:c2514582-2514412 [Mycobacterium leprae TN]
VLDKAKDILVQNADKVETVLDKAGEFVDEKAKGKYTDTIYQVAEETKKAASFDTFG

Nucleotide

• Length: 171 bp

>AT20342 NC_002677:c2514582-2514412 [Mycobacterium leprae TN]
GTGCTGGACAAAGCAAAGGACATACTGGTGCAGAATGCTGACAAAGTCGAAACGGTGCTCGATAAGGCCGGCGAGTTCGT
CGACGAAAAGGCGAAAGGCAAGTACACTGACACTATCTATCAGGTAGCTGAAGAGACCAAGAAGGCCGCTAGCTTTGACA
CTTTTGGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A197SER5