Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4127610..4128229 Replicon chromosome
Accession NZ_CP075286
Organism Klebsiella pneumoniae strain YTF44-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KI725_RS20705 Protein ID WP_002892050.1
Coordinates 4128011..4128229 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KI725_RS20700 Protein ID WP_002892066.1
Coordinates 4127610..4127984 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI725_RS20690 (KI725_20690) 4122762..4123955 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KI725_RS20695 (KI725_20695) 4123978..4127124 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KI725_RS20700 (KI725_20700) 4127610..4127984 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KI725_RS20705 (KI725_20705) 4128011..4128229 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KI725_RS20710 (KI725_20710) 4128388..4128954 + 567 WP_002892030.1 maltose O-acetyltransferase -
KI725_RS20715 (KI725_20715) 4128926..4129066 - 141 WP_004147370.1 hypothetical protein -
KI725_RS20720 (KI725_20720) 4129087..4129557 + 471 WP_002892026.1 YlaC family protein -
KI725_RS20725 (KI725_20725) 4129532..4130983 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KI725_RS20730 (KI725_20730) 4131084..4131782 + 699 WP_002892021.1 GNAT family protein -
KI725_RS20735 (KI725_20735) 4131779..4131919 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KI725_RS20740 (KI725_20740) 4131919..4132182 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T203418 WP_002892050.1 NZ_CP075286:4128011-4128229 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T203418 NZ_CP100084:343872-344240 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT203418 WP_002892066.1 NZ_CP075286:4127610-4127984 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT203418 NZ_CP100084:343654-343875 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References