Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4611481..4612138 Replicon chromosome
Accession NZ_CP075256
Organism Klebsiella pneumoniae strain SZP4-9-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KI741_RS22405 Protein ID WP_002916310.1
Coordinates 4611481..4611891 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KI741_RS22410 Protein ID WP_002916312.1
Coordinates 4611872..4612138 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI741_RS22385 (4607481) 4607481..4609214 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KI741_RS22390 (4609220) 4609220..4609933 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KI741_RS22395 (4609956) 4609956..4610852 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KI741_RS22400 (4610953) 4610953..4611474 + 522 WP_004144730.1 flavodoxin FldB -
KI741_RS22405 (4611481) 4611481..4611891 - 411 WP_002916310.1 protein YgfX Toxin
KI741_RS22410 (4611872) 4611872..4612138 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KI741_RS22415 (4612384) 4612384..4613367 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KI741_RS22420 (4613518) 4613518..4614177 - 660 WP_002916317.1 hemolysin III family protein -
KI741_RS22425 (4614341) 4614341..4614652 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KI741_RS22430 (4614702) 4614702..4615430 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KI741_RS22435 (4615549) 4615549..4616982 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T203399 WP_002916310.1 NZ_CP075256:c4611891-4611481 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T203399 NZ_CP100072:c5317081-5316698 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT203399 WP_002916312.1 NZ_CP075256:c4612138-4611872 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203399 NZ_CP100072:c5317323-5317081 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References