Detailed information of TA system TA203388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2764669..2766257
• Replicon: chromosome
• Accession: NZ_CP075256
• Organism: Klebsiella pneumoniae strain SZP4-9-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: KI741_RS13365
• Protein ID: WP_002904792.1
• Coordinates: 2764935..2766257 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: KI741_RS13360
• Protein ID: WP_002904790.1
• Coordinates: 2764669..2764935 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI741_RS13335 (2759699)	2759699..2760622	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
KI741_RS13340 (2760603)	2760603..2761757	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KI741_RS13345 (2762103)	2762103..2763482	+	1380	WP_032433093.1	nucleobase:cation symporter-2 family protein	-
KI741_RS13350 (2763460)	2763460..2763960	+	501	WP_032433095.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KI741_RS13355 (2763957)	2763957..2764283	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
KI741_RS13360 (2764669)	2764669..2764935	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KI741_RS13365 (2764935)	2764935..2766257	+	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
KI741_RS13370 (2766274)	2766274..2767566	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KI741_RS13375 (2767708)	2767708..2768712	-	1005	WP_032433097.1	fimbrial protein	-
KI741_RS13380 (2768700)	2768700..2771201	-	2502	WP_032433099.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaSHV-67	iroE	2679129..2863163	184034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T203388 WP_002904792.1 NZ_CP075256:2764935-2766257 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T203388 NZ_CP099990:924936-925298 [Staphylococcus equorum]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
TATCATACAGAATGATACTGGAAATAAATATAGTCCTACCGTAATTGTAGCTGCAATTACAGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAGCTTGATAAAGATTCTGTAATACTGCTTGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACATACCTTTCTGAAAGTAAAATGAAAGAAGTTAATGTTGCCATAGA
TATAAGCTTAGGATTACATAATGTTAGAAATAGTAAATCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT203388 WP_002904790.1 NZ_CP075256:2764669-2764935 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT203388 NZ_CP099990:924769-924939 [Staphylococcus equorum]
ATGGCAAGTTTTAATCAAAGCAGAAACCATAGTATTGAACAACTATTAAAAGAAGGCTATTCACAAATGGCCGATTTAAA
TCTCTCCCTTGCAGCAGAAGCATTTCCATTTGAATGTGAAGCTTGTGATTGCAATGAAGTTTACCTCAGCTCTAAGAATA
ACAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8

Antitoxin

• AlphaFold DB: A0A0H3GXD8