Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1396071..1396690 Replicon chromosome
Accession NZ_CP075256
Organism Klebsiella pneumoniae strain SZP4-9-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KI741_RS06655 Protein ID WP_002892050.1
Coordinates 1396071..1396289 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KI741_RS06660 Protein ID WP_002892066.1
Coordinates 1396316..1396690 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI741_RS06620 (1392114) 1392114..1392377 + 264 WP_032432663.1 type B 50S ribosomal protein L31 -
KI741_RS06625 (1392377) 1392377..1392517 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KI741_RS06630 (1392514) 1392514..1393212 - 699 WP_023287311.1 GNAT family protein -
KI741_RS06635 (1393313) 1393313..1394764 + 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
KI741_RS06640 (1394739) 1394739..1395209 - 471 WP_020802585.1 YlaC family protein -
KI741_RS06645 (1395230) 1395230..1395370 + 141 WP_004147370.1 hypothetical protein -
KI741_RS06650 (1395342) 1395342..1395908 - 567 WP_002892030.1 maltose O-acetyltransferase -
KI741_RS06655 (1396071) 1396071..1396289 - 219 WP_002892050.1 HHA domain-containing protein Toxin
KI741_RS06660 (1396316) 1396316..1396690 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KI741_RS06665 (1397176) 1397176..1400322 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KI741_RS06670 (1400345) 1400345..1401538 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T203387 WP_002892050.1 NZ_CP075256:c1396289-1396071 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T203387 NZ_CP099990:913627-913839 [Staphylococcus equorum]
GTGGTAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT203387 WP_002892066.1 NZ_CP075256:c1396690-1396316 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT203387 NZ_CP099990:913319-913612 [Staphylococcus equorum]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References