Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1396071..1396690 | Replicon | chromosome |
Accession | NZ_CP075256 | ||
Organism | Klebsiella pneumoniae strain SZP4-9-2 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | KI741_RS06655 | Protein ID | WP_002892050.1 |
Coordinates | 1396071..1396289 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | KI741_RS06660 | Protein ID | WP_002892066.1 |
Coordinates | 1396316..1396690 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KI741_RS06620 (1392114) | 1392114..1392377 | + | 264 | WP_032432663.1 | type B 50S ribosomal protein L31 | - |
KI741_RS06625 (1392377) | 1392377..1392517 | + | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
KI741_RS06630 (1392514) | 1392514..1393212 | - | 699 | WP_023287311.1 | GNAT family protein | - |
KI741_RS06635 (1393313) | 1393313..1394764 | + | 1452 | WP_004183206.1 | PLP-dependent aminotransferase family protein | - |
KI741_RS06640 (1394739) | 1394739..1395209 | - | 471 | WP_020802585.1 | YlaC family protein | - |
KI741_RS06645 (1395230) | 1395230..1395370 | + | 141 | WP_004147370.1 | hypothetical protein | - |
KI741_RS06650 (1395342) | 1395342..1395908 | - | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
KI741_RS06655 (1396071) | 1396071..1396289 | - | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
KI741_RS06660 (1396316) | 1396316..1396690 | - | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
KI741_RS06665 (1397176) | 1397176..1400322 | - | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
KI741_RS06670 (1400345) | 1400345..1401538 | - | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T203387 WP_002892050.1 NZ_CP075256:c1396289-1396071 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T203387 NZ_CP099990:913627-913839 [Staphylococcus equorum]
GTGGTAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA
GTGGTAACAAAAGTTATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCAGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT203387 WP_002892066.1 NZ_CP075256:c1396690-1396316 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT203387 NZ_CP099990:913319-913612 [Staphylococcus equorum]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |