Detailed information of TA system TA203384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 484883..486564
• Replicon: chromosome
• Accession: NZ_CP075256
• Organism: Klebsiella pneumoniae strain SZP4-9-2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: KI741_RS02320
• Protein ID: WP_015959269.1
• Coordinates: 485689..486564 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KI741_RS02315
• Protein ID: WP_004177809.1
• Coordinates: 484883..485641 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI741_RS02295 (480513)	480513..481199	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
KI741_RS02300 (481509)	481509..481652	+	144	WP_162897205.1	hypothetical protein	-
KI741_RS02305 (481649)	481649..483796	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KI741_RS02310 (484069)	484069..484797	+	729	WP_032413197.1	response regulator transcription factor	-
KI741_RS02315 (484883)	484883..485641	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KI741_RS02320 (485689)	485689..486564	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KI741_RS02325 (486689)	486689..487696	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
KI741_RS02330 (487771)	487771..488712	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KI741_RS02335 (488743)	488743..489741	-	999	WP_002885172.1	ribose ABC transporter permease	-
KI741_RS02340 (489738)	489738..491258	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T203384 WP_015959269.1 NZ_CP075256:485689-486564 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T203384 NZ_CP099979:1040037-1040303 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT203384 WP_004177809.1 NZ_CP075256:484883-485641 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT203384 NZ_CP099979:1039810-1040040 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05