Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 161769..162394 | Replicon | chromosome |
Accession | NZ_CP075256 | ||
Organism | Klebsiella pneumoniae strain SZP4-9-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | KI741_RS00805 | Protein ID | WP_002882817.1 |
Coordinates | 162011..162394 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | KI741_RS00800 | Protein ID | WP_004150355.1 |
Coordinates | 161769..162011 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KI741_RS00775 (157760) | 157760..158359 | + | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
KI741_RS00780 (158353) | 158353..159213 | + | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
KI741_RS00785 (159210) | 159210..159647 | + | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
KI741_RS00790 (159692) | 159692..160633 | + | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
KI741_RS00795 (160647) | 160647..161564 | - | 918 | WP_021466676.1 | alpha/beta hydrolase | - |
KI741_RS00800 (161769) | 161769..162011 | + | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
KI741_RS00805 (162011) | 162011..162394 | + | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
KI741_RS00810 (162568) | 162568..163497 | - | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
KI741_RS00815 (163494) | 163494..164129 | - | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
KI741_RS00820 (164126) | 164126..165028 | - | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T203383 WP_002882817.1 NZ_CP075256:162011-162394 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T203383 NZ_CP099976:c15227-14955 [Halomonas sp. Y3]
ATGCTGACCCCGGTCCGAACAAGCCAGTTCAAACGAGACGTGAAGCGGGTCCAGAAGCGCGGCAAGGACATGACCAAGCT
GCGGACCCTGCTTGGGCTGCTAATTGAGCAGGCCCCTTTACCCGAGGCCTACCAGGACCACCCCTTGAGAGGGAACTGGA
ACGGCTATCGGGATGCGCATATTGAGCCCGACTGGCTACTTCTGTATCGCATCGTGGATGATGAACTGCACCTGTCCCGA
ACGGGCAGTCATGCCGACTTGTTCCGTGAATGA
ATGCTGACCCCGGTCCGAACAAGCCAGTTCAAACGAGACGTGAAGCGGGTCCAGAAGCGCGGCAAGGACATGACCAAGCT
GCGGACCCTGCTTGGGCTGCTAATTGAGCAGGCCCCTTTACCCGAGGCCTACCAGGACCACCCCTTGAGAGGGAACTGGA
ACGGCTATCGGGATGCGCATATTGAGCCCGACTGGCTACTTCTGTATCGCATCGTGGATGATGAACTGCACCTGTCCCGA
ACGGGCAGTCATGCCGACTTGTTCCGTGAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT203383 WP_004150355.1 NZ_CP075256:161769-162011 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT203383 NZ_CP099976:c15484-15227 [Halomonas sp. Y3]
ATGAGTGCTGATACCGTGGTGAGAGCCCGCATCGACAGCGAGACCAAAGAGCGTGCCACCGCCGCCCTGGAGGCCATGGG
GCTGTCCGTGTCTGATGCCATTCGCTTGCTGATGCTGCGCATTGCAGACGAGAAGCGCCTGCCGTTTGCGGTGCAAGTGC
CGAACGCCACCACCACCAAGGCTATGGCCGAGCTGGACGCCGGCAAGGGGAAGCGGTTCGACAACGCCGATGAGCTGTTT
CAGGACCTGGGGATCTGA
ATGAGTGCTGATACCGTGGTGAGAGCCCGCATCGACAGCGAGACCAAAGAGCGTGCCACCGCCGCCCTGGAGGCCATGGG
GCTGTCCGTGTCTGATGCCATTCGCTTGCTGATGCTGCGCATTGCAGACGAGAAGCGCCTGCCGTTTGCGGTGCAAGTGC
CGAACGCCACCACCACCAAGGCTATGGCCGAGCTGGACGCCGGCAAGGGGAAGCGGTTCGACAACGCCGATGAGCTGTTT
CAGGACCTGGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |