Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3569958..3570559 Replicon chromosome
Accession NZ_CP075192
Organism Ferribacterium limneticum strain 132

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KI608_RS17100 Protein ID WP_226448320.1
Coordinates 3569958..3570263 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KI608_RS17105 Protein ID WP_226448322.1
Coordinates 3570260..3570559 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI608_RS17085 (KI608_17050) 3565499..3568378 + 2880 WP_226448318.1 PAS domain S-box protein -
KI608_RS17090 3568498..3568680 - 183 WP_226451924.1 hypothetical protein -
KI608_RS17095 (KI608_17055) 3568664..3569767 + 1104 WP_264180025.1 Na+/H+ antiporter NhaA -
KI608_RS17100 (KI608_17060) 3569958..3570263 + 306 WP_226448320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI608_RS17105 (KI608_17065) 3570260..3570559 + 300 WP_226448322.1 putative addiction module antidote protein Antitoxin
KI608_RS17110 (KI608_17070) 3570706..3571365 + 660 WP_226448324.1 hypothetical protein -
KI608_RS17115 (KI608_17075) 3571461..3572165 - 705 WP_226448326.1 ribulose-phosphate 3-epimerase -
KI608_RS17120 (KI608_17080) 3572388..3573425 - 1038 WP_226448328.1 fructose-bisphosphate aldolase class II -
KI608_RS17125 (KI608_17085) 3573542..3574561 - 1020 WP_226448330.1 type I glyceraldehyde-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3533650..3572165 38515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11241.88 Da        Isoelectric Point: 10.0877

>T203382 WP_226448320.1 NZ_CP075192:3569958-3570263 [Ferribacterium limneticum]
MIEIRKTDVFAQWLDSLRDIQARARIQVRIERLAAGNAGDAEPVGEGVSELRINHGPGYRVYFKKRGQELIILLAGGDKS
TQAKDIKTALRLARDLSEQAP

Download         Length: 306 bp

>T203382 NZ_CP099976:4532-4798 [Halomonas sp. Y3]
TTGGCCTGGCGGATTGAACTCACCGACGAGGCGGTCAAGCAGCTCAAGAAGATCGGTCATGCCGACGCCAAGCGCATTCG
GGACTATCTGCGCGGTCGCCTCCAGCCGCTGGAGGACCCCCGGCAGCTGGGCAAGCCGCTGACGGGCCAGCTCAGCGAGC
TGTGGCGCTACCGGGTAGGCAACTACCGCCTCATCGCCAGCATCGAGGATGACGAGATCCGTGTTCTCGTCGTGCGGATT
GGCCACCGTAGCAAGGTGTACCGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10535.93 Da        Isoelectric Point: 6.7171

>AT203382 WP_226448322.1 NZ_CP075192:3570260-3570559 [Ferribacterium limneticum]
MTKTATTRYDVAEHLRTQEEMAAYLEACLEEANGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGDRSPGFDT
ILKVVGALGLKLHAQANHG

Download         Length: 300 bp

>AT203382 NZ_CP099976:4324-4548 [Halomonas sp. Y3]
ATGCTCGCCCTACGCCTGCCCACTGAGATCGAGGAACGCCTGGAGGCCCTGGCCAAGGCCACCGGCCGCACCAAGAGTTA
TTACGCCCGCGAGGCGATCCTCGAGCACCTGGATGACCTCGAGGATATCTACCTGGCCGAGAAGACTCTGGAGCAGGTCC
GCCGCGGCGAGATGACGACCCACAGCCTGGACGACGTGGAGCGTGAGCTTGGCCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References