Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3569813..3570414 Replicon chromosome
Accession NZ_CP075191
Organism Ferribacterium limneticum strain 128

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KI617_RS17100 Protein ID WP_226448320.1
Coordinates 3569813..3570118 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KI617_RS17105 Protein ID WP_226448322.1
Coordinates 3570115..3570414 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI617_RS17085 (KI617_17050) 3565354..3568233 + 2880 WP_226448318.1 PAS domain S-box protein -
KI617_RS17090 3568353..3568535 - 183 WP_226451924.1 hypothetical protein -
KI617_RS17095 (KI617_17055) 3568519..3569622 + 1104 WP_264180025.1 Na+/H+ antiporter NhaA -
KI617_RS17100 (KI617_17060) 3569813..3570118 + 306 WP_226448320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI617_RS17105 (KI617_17065) 3570115..3570414 + 300 WP_226448322.1 putative addiction module antidote protein Antitoxin
KI617_RS17110 (KI617_17070) 3570561..3571220 + 660 WP_226448324.1 hypothetical protein -
KI617_RS17115 (KI617_17075) 3571316..3572020 - 705 WP_226448326.1 ribulose-phosphate 3-epimerase -
KI617_RS17120 (KI617_17080) 3572243..3573280 - 1038 WP_226448328.1 fructose-bisphosphate aldolase class II -
KI617_RS17125 (KI617_17085) 3573397..3574416 - 1020 WP_226448330.1 type I glyceraldehyde-3-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3533505..3572020 38515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11241.88 Da        Isoelectric Point: 10.0877

>T203375 WP_226448320.1 NZ_CP075191:3569813-3570118 [Ferribacterium limneticum]
MIEIRKTDVFAQWLDSLRDIQARARIQVRIERLAAGNAGDAEPVGEGVSELRINHGPGYRVYFKKRGQELIILLAGGDKS
TQAKDIKTALRLARDLSEQAP

Download         Length: 306 bp

>T203375 NZ_CP099975:1815833-1816096 [Halomonas sp. Y3]
ATGAGTAATCGACTGCTGTGCTGGACGGATGAGTCATGGCGTGATTATGTCTATTGGCAACGTCAAGATAAGAAAACGCT
AAAGAGAATCAATAAGCTAATAGCGGACGTCAAGCGCTCGCCGTTTGAAGGTATTGGTAAGCCCGAGCCACTAAAGGAGA
ACCTGTCCGGTTTTTGGTCTCGACGCATTGACGAATCAAACCGACTGGTTTACGTGGTGGAGGAGTCTTCGATCACGATC
CTCTCTTGCAGGTACCACTATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10535.93 Da        Isoelectric Point: 6.7171

>AT203375 WP_226448322.1 NZ_CP075191:3570115-3570414 [Ferribacterium limneticum]
MTKTATTRYDVAEHLRTQEEMAAYLEACLEEANGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGDRSPGFDT
ILKVVGALGLKLHAQANHG

Download         Length: 300 bp

>AT203375 NZ_CP099975:1815580-1815840 [Halomonas sp. Y3]
ATGAGGGTCGTGTCCTTTACCGAAGCAAGAAACGGGCTAAAGAGCGTGCTGGACAGTGTGATTAACGATGCCGATACGGC
CATCATTACACGTCGAGACTCTGAAGATGCCGTCGTGATGTCACTCGATTACTACAACAGCCTGATGGAAACCGTGCACC
TGCTTCGCTCCCCAGCGAATGCGGCACATCTGAACAAATCGATTGAGCAGTACCGTTCAGGAAAAGTCGTTGAGCGTAAG
TTGCTCGATGATGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References