Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2478110..2478675 Replicon chromosome
Accession NZ_CP075189
Organism Ferribacterium limneticum strain 77

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KI610_RS11945 Protein ID WP_226495188.1
Coordinates 2478110..2478481 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KI610_RS11950 Protein ID WP_226495189.1
Coordinates 2478478..2478675 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI610_RS11935 (KI610_11885) 2473313..2476879 + 3567 WP_226495186.1 AAA family ATPase -
KI610_RS11940 (KI610_11890) 2477068..2478021 + 954 WP_226495187.1 restriction endonuclease -
KI610_RS11945 (KI610_11895) 2478110..2478481 - 372 WP_226495188.1 type II toxin-antitoxin system VapC family toxin Toxin
KI610_RS11950 (KI610_11900) 2478478..2478675 - 198 WP_226495189.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI610_RS11955 (KI610_11905) 2478858..2479658 + 801 WP_226495190.1 alpha/beta fold hydrolase -
KI610_RS11960 (KI610_11910) 2479783..2480331 - 549 WP_226495191.1 peroxiredoxin-like family protein -
KI610_RS11965 (KI610_11915) 2480475..2481308 + 834 WP_226495192.1 AraC family transcriptional regulator -
KI610_RS11970 (KI610_11920) 2481476..2481811 - 336 WP_226495193.1 hypothetical protein -
KI610_RS11975 (KI610_11925) 2482023..2482457 + 435 WP_226495194.1 cache domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13274.32 Da        Isoelectric Point: 6.0641

>T203367 WP_226495188.1 NZ_CP075189:c2478481-2478110 [Ferribacterium limneticum]
MILVDTSIWIDHLRQRDERLSKLLNQGQVLAHPFVIGELALGSLQNRTAILGALQDLPQATVATEGEVLSFIEQNALYGI
GIGYIDAHLLAAVRLSPGATLWTRDKRLLAAGTGLGLVENAVH

Download         Length: 372 bp

>T203367 NZ_CP099973:c4072905-4072621 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7078.12 Da        Isoelectric Point: 7.0122

>AT203367 WP_226495189.1 NZ_CP075189:c2478675-2478478 [Ferribacterium limneticum]
MRTTLALDDDLLAKAHALTGVSEKTALIREALRALIQRESAKRLALLGGSEPQLEDAPRRQTEPA

Download         Length: 198 bp

>AT203367 NZ_CP099973:c4073137-4072895 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References