Detailed information of TA system TA203367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2478110..2478675
• Replicon: chromosome
• Accession: NZ_CP075189
• Organism: Ferribacterium limneticum strain 77

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KI610_RS11945
• Protein ID: WP_226495188.1
• Coordinates: 2478110..2478481 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KI610_RS11950
• Protein ID: WP_226495189.1
• Coordinates: 2478478..2478675 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI610_RS11935 (KI610_11885)	2473313..2476879	+	3567	WP_226495186.1	AAA family ATPase	-
KI610_RS11940 (KI610_11890)	2477068..2478021	+	954	WP_226495187.1	restriction endonuclease	-
KI610_RS11945 (KI610_11895)	2478110..2478481	-	372	WP_226495188.1	type II toxin-antitoxin system VapC family toxin	Toxin
KI610_RS11950 (KI610_11900)	2478478..2478675	-	198	WP_226495189.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KI610_RS11955 (KI610_11905)	2478858..2479658	+	801	WP_226495190.1	alpha/beta fold hydrolase	-
KI610_RS11960 (KI610_11910)	2479783..2480331	-	549	WP_226495191.1	peroxiredoxin-like family protein	-
KI610_RS11965 (KI610_11915)	2480475..2481308	+	834	WP_226495192.1	AraC family transcriptional regulator	-
KI610_RS11970 (KI610_11920)	2481476..2481811	-	336	WP_226495193.1	hypothetical protein	-
KI610_RS11975 (KI610_11925)	2482023..2482457	+	435	WP_226495194.1	cache domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-109)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13274.32 Da
• Isoelectric Point: 6.0641

>T203367 WP_226495188.1 NZ_CP075189:c2478481-2478110 [Ferribacterium limneticum]
MILVDTSIWIDHLRQRDERLSKLLNQGQVLAHPFVIGELALGSLQNRTAILGALQDLPQATVATEGEVLSFIEQNALYGI
GIGYIDAHLLAAVRLSPGATLWTRDKRLLAAGTGLGLVENAVH

Nucleotide

• Length: 372 bp

>T203367 NZ_CP099973:c4072905-4072621 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7078.12 Da
• Isoelectric Point: 7.0122

>AT203367 WP_226495189.1 NZ_CP075189:c2478675-2478478 [Ferribacterium limneticum]
MRTTLALDDDLLAKAHALTGVSEKTALIREALRALIQRESAKRLALLGGSEPQLEDAPRRQTEPA

Nucleotide

• Length: 198 bp

>AT203367 NZ_CP099973:c4073137-4072895 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA